Aim and Background: This study aimed at investigating the effectiveness of dialectical behavior therapy techniques in reducing catastrophizing, fear of movement, pain disability, and pain intensity in musculoskeletal chronic pain sufferers.Methods and Materials: This study is a single subject investigation based on multiple baseline design which is one of quasi-experimental research methods. The participants were two women suffering chronic back pain who were selected through purposive non-random sampling method among clients of Pain Clinic of Tabriz, based on pain specialist diagnosis, clinical interview and screening tools. The protocol was conducted in 12 and 60-minute sessions. Also two baseline sessions and one month follow up session were added. Catastrophizing, fear of movement, pain disability and pain intensity questionnaires were filled by subjects in 5th, 7th, 9th, 11th, 14th baseline sessions and the follow up session. Treatment results were investigated through visual inspection method.Findings: According to our results, Dialectical Behavior Therapy was effective in reducing catastrophizing, fear of movement, pain disability and pain intensity. Also these effects were maintained in patients to a large extent in the follow up session.Conclusions: Psychological as well as medical treatment can be helpful in patients with chronic musculoskeletal pain.