Passive defense measures in architecture and urban planning can be effective in reducing the risk against a variety of natural hazards, in addition to its premiere purpose in reducing the damage of man-made threats like wars. Medical and health centers as one of the basic and vital needs in emergencies should be designed and built in such a way to meet the defined standards of security against accidents and threats and achieve the overall goals of passive defense. In emergencies, these centers should not be vulnerable at all or have the least vulnerability depending on the functional level. In fact, a safe hospital is a kind of medical shelter that makes the conditions of hospitalization and treatment possible away from external threats in times of crisis. Shahid Beheshti Medical Research and Training Center in Qom is the largest medical center in the Qom province. Because of the need to redesign this hospital according to the principles of passive defense, the relevant design requirements based on factors such as location, dispersion, camouflage, fortifications, facilities, architecture design, repairability, etc. have been studied, and based on the presented principles, appropriate solutions are provided. The research method is descriptive-analytical and the data are obtained from documentary sources, libraries and field observations. Using the descriptive-analytical method, it is shown that the design of the hospital in terms of the building form, location, emergency storage, access, proximity to public spaces and parking area, is consistent with the principles of passive defense. Studies also show that the hospital does not comply with the principles of passive defense in terms of facade, safe haven, camouflage, green space design and safety indicators. We conclude that in the design and implementation processes, all the principles of passive defense for the protection of buildings of high importance should be considered.