Purpose: To identifying and determining the attributes of the Iranian-Islamic information contexts' manuscripts from the point of information and knowledge organization. Methodology: The research was considered as a developmental-applied research that done content analysis method. The attributes (data) of Iranian-Islamic information context's manuscripts were extracted by using the Delphi technique and Documentation method. 14 experts in the field of manuscripts studies, and information and knowledge organization were selected by targeted sampling. A questionnaire was also used to identifying the attributes of the Iranian-Islamic information context's manuscript. Findings: To description and organization of the Iranian-Islamic information context's manuscript are needed 19 main attributes and 224 sub-attributes. The main attributes are: title, author, type of manuscript, originality, classification, identifier, holdings, access condition, custody, content structure, transcription, subject, correction, rights, language, related objects, Certificates of transmission (Ijā zah), Physical description, and Note. Conclusion: The results of this research can be used to create a useful metadata application profile for describing and organizing of Iranian-Islamic information context's manuscript, especially in the electronic environment. For researchers provides appropriate access points to improve accessibility to these valuable resources, which will lead to the development of manuscriptology and the increase of relevant scientific outputs.