Studies have indicated that anthropometric measurements and hand dimensions may be effective on hand grip strength and relationship between these dimensions with hand grip strength can predict the success and recognition of athletes who are prone. The purpose of the present study was to examine the relationship of handgrip strength with basic anthropometric variables, upper extremity anthropometric variables and specific hand anthropometric variables and comparison it in athletes and non-athletes men.In order to, we selected 200 male subjects includes 100 student non-athletes (age: 21.14±2.13 yrs, Height: 174.98±5.46 cm, weight: 68.6±10.47 kg) and 100 student athletes (age: 21.66±1.96 yrs, Height: 179.13±6.5 cm, weight: 73.65±8.7 kg). Height, weight, body mass index (BMI) and percent body fat, arm length, forearm length, forearm and hand forearm length, elbow breadth, palmar breadth, wrist breadth, arm circumference, forearm circumference, wrist circumference and specific hand anthropometric variables includes: fingers span, fingers length and fingers perimeter was measured in all subjects. Data were analyzed with independent sample t-test, Pearson and Spearman correlation coefficient, unilateral variance analysis (ANOVA) and stepwise multiple regression statistical models. Level of significant in this study was p<0.05. The findings of this study showed that handgrip strength had a significant relationship with weight, body mass index (BMI) and percent body fat, arm length, arm circumference, forearm circumference, wrist circumference and fifth fingers length in athlete group (p<0.05) and so showed significant relationship with weight, body mass index (BMI), percent body fat, arm length, forearm length, forearm and hand forearm length, arm circumference, forearm circumference, wrist circumference, palmar breadth, wrist breadth, index finger length and fifth finger span in non-athlete group (p<0.05). These findings indicate that anthropometric variables and type of exercise are effective on handgrip strength.