Background & Aims The role of the family in the health of the child is very vital because a major part of a child’, s development. The present study investigates the health behaviors and related factors in mothers of hospitalized children in Kashan, Iran. Materials & Methods This cross-sectional study was conducted on 216 mothers of children hospitalized in children’, s wards of two teaching hospitals in Kashan from November 2019 to March 2021. Meanwhile, sampling was done through continuous sampling. The first author (a nurse in the children’, s wards) indirectly observed the mothers’,health-related behaviors toward their children and then immediately recorded them using a checklist. Data were then analyzed in SPSS software (v. 26) using descriptive statistics, Pearson correlation test, one-way ANOVA, independent t-test, and linear regression analysis. Results The mean age of mothers of hospitalized children was 29. 27±, 5. 60 years. Based on the results, the following items had the highest compliance scores: “, use of fresh and safe drinking water for the child”,(97. 5%), “, washing hands with soap and water in case of clear hand contamination”,(95. 6%), “, Changing the child’, s clothes and bedding as soon as they become contaminated with diarrhea, vomit, blood, and other contaminants”,(90. 7%), and “, Washing hands after changing the child’, s diaper”,(87. 3%). On the other hand, some other items, including “, washing hands before changing the child’, s diaper”,(8%), “, covering the mobile phone with a plastic to avoid contamination”,(8. 8%), and “, washing hands with soap and water after touching the surrounding surfaces”,(15. 8%), had the lowest compliance scores. Conclusion The results indicated that mothers failed to comply with behaviors such as washing their children’, s hands regularly and washing their own hands before breastfeeding. It is necessary to teach and inform them regarding the observation of behaviors related to the child’, s health upon entering the hospital to ensure their child’, s safety.