Introduction: Cardiovascular diseases have a high prevalence in the world and are considered one of the main causes of death. To reduce the prevalence and mortality of heart diseases, pharmacological and non-pharmacological measures are considered. Medicine is the main link in the treatment chain and its correct use is important. In the field of non-pharmacological measures, strategies to deal with negative emotions such as stress, anxiety, and depression are considered because they can cause and aggravate heart diseases. This study investigated the relationship between the management of the principled use of drugs with stress, anxiety, and depression in patients with coronary artery disorders. Methods: This research is a correlational descriptive study in which 115 patients with coronary artery disease or class one and two heart failure with medical records the only hospital in Gonabad city was selected and examined by a simple random method based on the inclusion criteria. The DASS-21 questionnaire and the researcher-made questionnaire for the management of the basic use of drugs along with demographic information were provided to the samples. After determining normality using Spearman's test and regression analysis and using descriptive statistics methods (prevalence, percentage, mean, standard deviation) and using SPSS version 25 software Results: Based on the results of Spearman's test, there was a significant and inverse relationship between the management of basic medication use and DASS (p<0. 05, r=-0. 28). Also, there was a significant and inverse relationship between the dimensions of DASS including anxiety (r=-0. 24), stress (r=-0. 27), and depression (r=-0. 22) with the management of the principal use of drugs Conclusions: In this study, the relationship between stress, anxiety, and depression with the management of basic medication use in patients with coronary artery disorders was investigated, and there was a significant and inverse relationship between the management of basic medication use and stress, anxiety, and depression. Therefore, it can be said that the higher the level of stress, anxiety, and depression, the more people will be in a weaker position in terms of managing the basic use of drugs.