Introduction: In any job, performing job tasks requires different psychological demands, physical demands and workload, which can lead to physical and psychological problems in the employee. Therefore, the aim of the current research was to predict the health (organizational stress, health complaints, exhaustion and fatigue) of employees from the psychological demands of the job, physical demands, workload, and opportunities for development, possibilities for professional development and financial rewards in a company affiliated to the Ministry of Oil in Isfahan. Methods: The participants of this descriptive-correlation study were 362 employees of a company affiliated to the Ministry of Oil in Isfahan, who were selected randomly using a table of numbers. Research instruments include, demographic questionnaire, "Psychological Job Demands Scale", "Physical Demands Scale", "Workload Scale", "Opportunities for Development Scale", "Possibilities for Professional Development Scale", "Financial Rewards Scale", "Organizational Stress Questionnaire", "Perceived Health Complaints Scale", "Maslach Burnout Inventory-General Survey”,and “, Chalder Fatigue Scale”, . The validity of the instruments was measured using the face and concurrent validity. Reliability was confirmed by internal consistency method by calculating Cronbach's alpha coefficient and stability by retest method. Data analysis was done in SPSS. 20 software. Results: Psychological demands, physical demands and workload, positively in the order of organizational tension (β, =17. 01, β, =29. 02, β, =22. 03, P<0. 05), health complaints (β, =15. 01, 17 β, =/02, β, =03. 23, P<0. 05), burnout (β, =19. 01, β, =12. 02, P<0. 05) and fatigue (β, =22. 01, β, =02. 15), β, =03. 17, P<0. 05) and opportunities for development, possibilities for professional development and financial reward, negatively in the order of organizational burnout (β, =1-0. 18, β, =2-0. 15, 12/ β, =3-0, P<0. 05), health complaints (β, =1-0. 14, β, =2-0. 17, β, =3-0. 15, P<0. 05), fatigue (0. 11 β, =-1, β, =2-0. 13, β, =3-0. 15, P<0. 05) and fatigue (β, =1-0. 14, β, =2-0. 16, β, =3-0. 18 =β, , P < 0. 05). Conclusions: Employee health is improved by increasing psychological demands, physical demands and work load, and by increasing opportunities for development, possibilities for professional development, and financial rewards. Therefore, in order to improve the health of employees, psychological demands, physical demands and workload should be reduced and opportunities for development, possibilities for professional development and financial rewards should be increased.