The purpose of the current study was to determine the direct and indirect effects of personality characteristics, emotions, and perceived stress on stress coping styles. In this correlational study, path analysis was used to investigate the relations between variables in a structural equation model. The participants were 200 Hamadanian citizens that were selected using random multi-stage cluster sampling. The participants were asked to complete Differential Emotions Scale (Izard, Libero, Putnam & Haynes, 1993), HEXACO personality Inventory (Ashton & Lee, 2004), Coping Styles Questionnaire (Billings& Moos, 1981) and Perceived Stress Scale (Cohen, Kamarck, & Mermelstein, 1983). Data were analyzed using correlation coefficient and path analysis. The result showed that Conscientiousness, positive and negative emotions, and positive perceived stress have direct significant effect on problem-focused style. The highest effect in the model belongs to the direct effect of positive perceived stress on problem-focused style. In this article, the predispositional role of personality and emotions for stressful experiences and coping style selection has been discussed.