Introduction: Evaluation of objective experiences of health services users is essential for evidence-based health policy-making and planning. Accordingly, research on postpartum quality of life has attracted increasing attention. The aim of this study was to determine factors affecting postpartum quality of life of women in Shiraz. Materials and Methods: This cross-sectional study was performed among 1050 mothers in Shiraz in 1400. A proportional multistage stratified sampling method was used to select participants. Data were collected using two general and specific scales for measuring postpartum quality of life. Data were analyzed using analysis of variance and multiple linear regression. Results: Multiple linear regression showed that water birth (β, =0. 83, P=0. 001), natural vaginal delivery (β, =0. 70, P=0. 002), housekeeping (β, =0. 71, P=0. 011), university education (β, =0. 68, P=0. 028), basic education (β, =0. 23, P=0. 043), and living in the cities (β, =0. 21, P=0. 041) had the greatest impact on the postpartum quality of life of women, respectively (R2=0. 861, df=7). Conclusion: Findings indicate that method of delivery, level of education, employment status and place of residence were among the most important factors affecting postpartum quality of life. Identification of determinants of postpartum quality of life considering clinical justifications and economic analysis can provide the necessary evidence for the selection of appropriate childbirth methods.