Introduction: Mental workload is one of the factors that influence the behavior, performance and efficiency of nurses in the workplace. There are diverse factors that can affect the mental workload level. The present study aimed to investigate the mental workload and its determinants among nurses working at one hospital in Kermanshah City, Iran.Methods: In this cross-sectional study, 203 nurses were selected from 5 wards of infants, emergency, surgery, internal and ICU and surveyed. Data collection tools were demographic and NASA-TLX questionnaires. The data were analyzed using Independent sample t-test, ANOVA and statistics descriptive with the SPSS 16 software.Results: The mean (standard deviation) of overall mental workload was 69.73±15.26. Among different aspects of mental workload, the aspect of "effort" with an average score of 70.96±15.23 was the highest and the aspect of "frustration and disappointment" with an average score of 44.93±25 was the lowest one. There were significant relationships between the physical aspect of workload with age, type of shift working, number of shifts, type of employment, between temporal aspect of workload with BMI, type of employment and work experience, and between the aspect of effort and BMI (P £ 0.05).Conclusions: Due to the different amounts of mental workload in the studied hospital wards, relocation of nurses between wards can improve the situation and increase in the number of nurses can lead to decrease mental workload.