Nowadays, following the development of agriculture, there are concerns about adverse environmental consequences such as water, soil, air pollution, fertility reduction, soil erosion, and resource depletion based on the use of non-renewable inputs, which require a solution in this regard. This study was conducted in Gorgan and Zahedan counties during the agricultural year of 2018-2019 to evaluate the environmental impacts caused by the acidification and eutrophication of the terrestrial ecosystem and resource depletion. In this study, water consumption, vermicompost fertilizer, nitrogen fertilizer nano chelate, phosphorus nano chelate, potassium fertilizer nano chelate, and chemical fertilizer consumption (from the source of urea, triple superphosphate, and potassium sulfate) are considered as inputs susceptible to environmental damage. In general, for one ton of purslane forage production, Gorgan County creates fewer ecological burdens than Zahedan County due to less consumption of inputs in all impact sectors. Based on the final index results, it concluded that the highest environmental damage potential in Zahedan County is related to the impact group of water resources depletion with the amount of 3.18 m3, and in Gorgan County, related to the impact group of terrestrial ecosystem acidification with the amount of 1.608 kilograms is equivalent to one kilogram of SO2 in the production of one ton of purslane forage, and the lowest environmental damage potential in both the cities of Zahedan and Gorgan is related to the groups of phosphate and potassium depletion with partial amounts. Based on the evaluation results of the ecological index (Eco-X) and the resource depletion index (RDI) per ton of purslane forage production, Zahedan County has a higher ecological index (Eco-X = 3.387) than Gorgan County (Eco-X = 2.899) and created more ecological burdens. However, the resource depletion index (RDI) was calculated for Zahedan County as (RDI = 3.188) and Gorgan County as (RDI = 1.456).