Introduction: The role of heart failure in reducing the quality of life is approved. However, with regard to the impact of a healthcare plan based on the Pender health promotion model on quality of life, there are few studies with conflicting results on this group of patients. Objective: The current study aimed at investigating the effect of a healthcare program based on Pender Health Promotion Model on quality of life in patients with heart failure in a military hospital. Materials and Methods: In the current clinical trial, 48 patients with heart failure (grades 2 and 3) referred to the heart clinic of a military hospital in 2017 were selected by the purposive sampling method and randomly divided into two groups including the case (n=24) and the control (n=24) groups. In order to assess the quality of life, the SF-36 standard questionnaire with confirmed validity and reliability was used. Then, a healthcare program developed based on the Pender health promotion model-based care program was performed in the case group. The quality of life of patients was assessed in both groups in pre-test and post-test. Data were analyzed with SPSS version 21 using statistical tests such as independent t test, paired t test, chi-square, the Mann-Whitney U and the Fisher exact tests. P<0. 05 was considered the level of significance. Results: The results of independent t test showed no significant difference in the total score of quality of life and its dimensions between the two groups prior to implementation of the healthcare plan (P<0. 05). However, after the intervention there was a significant difference between the mean score of the subjects in the case group in terms of the dimensions: physical functioning, physical role functioning, public health, vitality, social role functioning, and mental health, and also between intervention and control groups in the total score of quality of life in favore of the intervention group (P<0. 05); however, after the intervention no significant difference was observed between the mean score of the subjects in both groups in terms of the following dimensions: bodily pains and emotional role functioning (P<0. 05). Moreover, according to the results of paired t test, there were no significant differences among the subjects of the control group in physical functioning, physical role functioning, public health, vitality, social role functioning, and mental health after the intervention (P <0. 05); however, after the intervention there was a significant difference between the mean score of the subjects in the control group in bodily pains and emotional role functioning (P <0. 05). In addition, before and after the intervention there was a significant difference between the mean score of the subjects in the intervention group in all dimensions, except emotional role functioning (P <0. 05). Discussion and Conclusion: Use of a health care program based on the Pender health promotion model significantly affected the quality of life in patients with heart failure. Therefore, it is recommended to take appropriate measures by nurses, administrators, and other health care providers in order to improve the quality of life of such patients.