Study of the discourses on epistemology of the Qur'an is among the present century's epistemological trends which only few of the Qur'an experts and authorities have dealt with. Cognition of the procedures for achieving knowledge (ma‘rifat) about the Origin (mabda‘) and Return (ma‘ād) in the Qur'an, or in other words, the cognition of guiding procedures of the Qur'an requires to recognize the instruments that the Qur'an has provided for man's [achieving] knowledge.This article addresses two issues: "the Qur'an's approach to the instruments and ways to ma‘rifat" and "their relation to the principles of Qur'anic worldview". First, it proceeds to prove, with the examination of the instruments of cognition in the Qur'an, that the Qur'an has provided man with two ways to ma‘rifat. In the first way, some instruments of human components are his guide in cognition of the Origin, but due to the restrictions of these instruments in the material world and the possibility of their being flawed, another way for achieving ma‘rifat has been recommended to man which is beyond human faculties and senses, and secure from any flaws and quite reassuring, so that man may achieve cognition about the reality of the Origin as well as the existence of the Return and how it is accomplished. This way to ma‘rifat, which people achieve through the Prophets, is the firmest and most essential way and a touchstone for verifying human epistemic instruments. The second issue studied and explained in this article is the sovereignty of the three principles of the Qur'anic worldview over cognition instruments.