Introduction: Today, addiction to illegal drugs and also their toxicities and their detrimental psychological, and social outcomes, are among the life-threatening health problems throughout the world. This study was aimed to compare the personality traits (five great factors) and spiritual intelligence in addicted and non-addicted males in Ilam province in 2014.Material and Methods: In this cross-sectional and causal-comparative study, 80 drug- addicted males referring to addiction treatment centers in Ilam were compared with 80 healthy individuals who were matched in terms of gender, age, educations and marital status. Data were collected using the NEO Personality characteristics and spiritual intelligence Scale of King and were analyzed using MANOVA.Results: The results showed that there was a significant difference between personality characteristics and spiritual intelligence in addicted and non-addicted males. While the addicted individuals had higher scores (37.17) in neuroticism dimension (p<0.010), their scores for the parameters of extraversion, agreeableness, conscientiousness and spiritual intelligence were lower (p<0.010). No significant differences were found between the two groups for the parameter of empiricist.Conclusion: Based on these findings, we can conclude that personality characteristics and spiritual intelligence can be an influential factor in drug abuse therefore, it is suggested that these variables be considered for treatment of drug-dependent persons.