Introduction: The design of a benefit package is a key tool to direct health systems to the universal health coverage. Decision making on service prioritization takes into account information on cost-effectiveness, the impact of financial protection, and equity in access to services. To this end, health technology assessment (HTA), which has legal backing and evidence-based protocols, can be used. Therefore, the current study aimed at determining the role of health technology assessment in the package of designing. Methods: The current review study collected and analyzed the available evidence. The search was conducted to identify related studies in the electronic database (Cochrane Library, Scopus, PubMed, Trip, and Google Scholar) without any time limit and by August 2018 with proper keywords and strategies for each database. Results: Out of the 132 studied articles, only two studies were selected according to the inclusion and exclusion criteria. These two studies described the experience of Thailand and the Netherlands regarding the role and application of health technology assessment in determining the benefits package. The Thai study described the hierarchy and sequence of how to determine the choice of services to be included in the benefit package, and the Dutch study referred to the policy and implementation levels and the infrastructure needed to establish a health technology assessment system to determine the benefit package. Conclusions: According to the advancement of technologies (drugs, equipment, and diagnostic tests), cost growth, and the lack of resources in the health system, it is suggested to select a benefit package focusing on health technology assessment studies. HTA is useful to inform health system decision makers about package coverage since it increases transparency, participation, and accountability in the process. Accordingly, a five-step model is recommended to determine the benefit package.