Daneshvar Medicine: Basic and Clinical Research Journal
Year:2013 | Volume:20 | Issue:104|Papers Count:14

gastrointestinal infections worldwide. Infection with H. pylori strains may results in different pathological manifestation and increased oxidative stress lead to a strong inflammatory response in gastric mucosa. There is continuing interest in identifying H. pylori virulence factors that might predict the risk for symptomatic clinical outcomes. The purpose of this study was to evaluate the prevalence of cagA and vacA genes in patients with peptic ulcer.Materials and Methods: The presence of IgG antibody against CagA and VacA proteins was determined by using Western blotting technique. The presence of cagA gene and vacA alleles was examined by PCR. H. pylori-positive patients including PUD and NUD were used for these experiments.Results: Biopsies were considered as H. pylori-positive and negative when both the rapid urease test and bacterial culture gave positive and negative results, respectively. H. pylori-positive, cagA-positive, and vacA alleles (s1 and m2) were predominant in all clinical outcomes. There was no significant association between prevalence of CagA and VacA status and clinical outcomes.Conclusion: Our results suggest that cagA-positive strains were predominant in patients. However, we found no association between cagA and vacA status and clinical outcomes and this virulence factor is not associated with the development of PUD. In addition, serological tests such as the western blotting are helpful in detecting subjects infected with H. pylori strains in PUD and NUD.

Background and Objective: Studies have shown that there is a connection between psychological disorders symptoms and sexual dysfunctions. The aim of this study was to examine the connection between psychological disorders symptoms and sexual dysfunction and also to determine the role of psychological disorders symptoms in the development of sexual dysfunctions.Materials and Methods: In this study, 200 individuals (115 females and 75 males) who referred to psychological clinics in Tehran and Karaj (from 2011 till 2012) were included with a convenient sampling method. All individuals were asked to complete FSFI (for females), IIEF (for males) and SCL-90 scales. Correlation and hierarchical regression were used to analyze the data.Results: The findings revealed that there is a significant correlation between psychological disorders symptoms and sexual dysfunctions. Hierarchical regression showed that psychological disorders symptoms (especially phobia, depression, OCD, somatic problems and paranoia symptoms) can remarkably predict sexual dysfunctions.Conclusion: There is a significant relationship between psychological disorders symptoms and sexual dysfunctions. Symptoms of some of psychological disorders can explain sexual dysfunctions. Findings of this study are consistent with some other previous researches.

Background and Objective: Surface roughness can increase the retention of castings by sandblast that are micro retentive. This study compared the retention of implant-supported crowns when used with 3 different surface roughness abutments and one temporary cement.Materials and Methods: Thirty abutments (DIO implant-cemented abutment, SAC 4814N (II)) were divided in three groups. First group was standard machine surface, second group sandblasted with 25 micron aluminum oxide particles and third group was sandblasted with 50 micron particles. Then, regular diameter implant analogs were embedded in resin acrylic block and provisional cement kerr Temp bond NE was used for cementation.90 metal coping were fabricated and after cementation the aging processing was done. Then, the retentive strength was tested with universal testing machine at cross head speed of 0.5 mm/min. Results were analyzed using One way ANOVA and Tukey's test.Results: Retentive strength of temp bond kerr with 50 micro sanbblasted abutment was statistically different than two other groups (p<0.001). Between all the groups, standard abutment was the weakest.Conclusion: Surface modification of implant abutment by sandblast may be an effective method to increase retention of crown when provisional luting cement is used.

Background and Objective: Tolerance and dependence are two major problems of chronic opioids use. Repeated application of Lavandula officinalis has been recommended for a long time in Iranian traditional medicine for some of nervous disorders like epilepsy and dementia. Since anti-convulsant drugs are beneficial in treatment of morphine dependence and with regard to anti-convulsant effects of Lavandula officinalis, the effects of Lavandula officinalis extract (LOE) was studied on acquisition and expression of morphine tolerance and dependence and it was compared with methadone.Materials and Methods: Morphine was injected either acutely (100 mg/kg) or chronically, with gradually increasing doses twice daily for 7 days, except in 8th day in which morphine was administrated at a single dose (100 mg/kg). In either acutely or chronically with saline, LOE 200 mg/kg, LOE 400 mg/kg, methadone 5 mg/kg, methadone+LOE 200, methadone+LOE 400 was administrated 60 min prior to morphine injection. Morphine tolerance was measured by tail immersion test, before and after administration of morphine in test day. Morphine dependence was also evaluated by counting the number of jumps after injection of naloxone (5 mg/kg) in test day. All drugs were given at a volume of 0.3 ml intraperitoneally.Results: LOE and methadone significantly decreased acquisition (but not expression) of morphine tolerance and dependence (p<0.05). Chronic administration of LOE but not methadone reduced physical dependence induced by single dose of morphine (p<0.05).Conclusion: Chronic administration of Lavandula officinalis inhibits morphine tolerance and dependence in mice better than methadone.

Background and Objective: Smoking cessetation can prevent death of four million people around the world but its succession rate is low. The aim of this study was to determine the effectiveness of educational program on smoking cessation consistence based on trans-theoritical model (TTM).Materials and Methods: In the randomized clinical trial study, 110 smokers who were allocated to control and treatment groups in Khomein in Arak city in 2012. Data collection with standard measure based on TTM construct and fagernstrom test (FNDT). Treatment group received five sessions of person counceling and nicotine replacement thrapy (NRT) with nocotine chewing gum, line follow up and self help manual. After 3 and 6 months of assessment of smoking cessation, data were finally analyzed using statistical Chi-square, t-test and t-paired tests.Results: The mean age of participants in treatment and controll groups was 39.16±9.12 and 38.12±9.14 year, respectively and the difference was not significant (p=0.32). Before intervention, the mean of dependent nicotine in control and tratment groups was 5.12±2.12 and 5.49±2.76, respectively based on FNDT and after 6 months of follow-up in treatment group, it significantly decreased (p=0.02).Conclusion: Performing simultaneous intervention including person counceling, NRT and line follow-up is very beneficcial in people who are in preparation stage and should be considered in cessetion programs.

Background and Objective: Dyslipidemia is one of the consequences of overweight and obesity. Hence, this research was conducted to compare the effectiveness of behavior-nutritional and Beck cognitive therapy in combination with dietary-physical activity prescriptions on declining overweight and modifying lipid profile among overweight and obese women.Materials and Methods: Applying semi-experimental design and using convenient sampling method, 32 volunteer women with BMI≥25 eligible to exclude-include criteria were selected and randomly assigned into two experimental groups (each group included 16 subjects). Prior to, after, and 3 months after each intervention, all participants' weight, height, and lipid profile were measured.Results: Data analysis with SPSS (16th version) and applying repeated measures analysis of variances method revealed that both interventions could significantly decrease the weight, TG and TC (p<0.05), and HDL significantly increased (p<0.05) too. But there were no significant differences between two interventions (p<0.05) except for LDL level.Conclusion: It appears that different psychological interventions in combination with dietary-physical activity interventions focused on multidisciplinary (bio-psycho-social) approaches for modifying them with controlling overeating and correcting sabotaging beliefs and behaviors could decrease weight and improve lipid profile.

Background and Objective: Recent studies have demonstrated that obesity–induced oxidative stress and inflammation are risk factors for breast cancer. The aim of this study was to determine the relationship of the pro-inflammatory markers, lipid peroxidation and body fat percentage after 6 weeks of regular water-based exercise and ginger supplementation in obese women with breast cancer.Materials and Methods: In a semi-experimental study, forty obese women diagnosed with breast cancer with a weight of 76±9 kg and a fat mass of 41.8±4 percent were randomly divided into four groups: placebo, water-based exercise, ginger supplementation and a combined group of water-based exercise and ginger supplementation. Subjects of the ginger supplement and combined group received 4 capsules of ginger powder on a daily basis (each capsule contained 750 mg) for 6 weeks. The water-based exercise training program was collected at a progressive intensity and time: 4 times a week for 6 weeks.Results: Implementation of water-based exercise, ginger supplementation and the combined programs caused a significant decrease in concentration of interleukin-6 (IL-6) and C-reactive protein (CRP), malondialdehyde (MDA) and fat mass. However, considering Pearson correlation coefficient, it was concluded that just the relationship between fat mass and MDA in the ginger supplementation group was significant (r=0.63, p=0.05).Conclusion: Although performing water-based exercise and ginger supplementation programs attenuate systemic inflammation and oxidative stress in obese women with breast cancer, there was no relationship between stress and changes of pro-inflammatory markers.

Background and Objective: The history of psychology is full of concepts evolved to upgrade and improve therapies and mental health. The Compassionate Focused Therapy (CFT) model is rooted in the concept of self-compassion in modern psychology. The purpose of this research was to study the effectiveness of CFT on depression, anxiety, and rumination of depressed patients according to their self-compassion trait.Materials and Methods: This study was designed as an experimental pretest-posttest with an equivalent control group. Nineteen depressed patients with available sampling were selected from a psychiatric clinic and randomly divided into two groups. The experimental group participated in 12 sessions of Compassion Focused Group therapy (CFT). All participants were assessed by Beck Depression Inventory-II (BDI-II), Anxiety Scale (AS), Rumination Scale and Self-Compassion Scale (SCS) at the beginning, final session and two months after the intervention (follow-up study). Data were analyzed by ANOVA and independent samples t-test with SPSS 18.Results: According to data analysis, depression and anxiety of the experimental group significantly decreased in the follow-up study (p<0.05). In addition, the interaction between intervention and self-compassion was significant on the rumination.Conclusion: This study showed that CFT could be an effective therapy for depression and anxiety of depressed patients. In addition, people who had higher levels of self-compassion benefited more from our intervention and their rumination decreased. On the other hand, people who had lower level of self-compassion experienced increased rumination.

Background and Objective: Microleakage is one of the most important problems in dentistry. Varnish is commonly used to reduce microleakage. Nanotechnology has recently produced cosmetic dental materials with better mechanical properties. The aim of this study was to compare the microleakage of dental restorations using traditional varnish and varnish containing nano-silver.Materials and Methods: In this research study, for preparing a nano-silver varnish, nano- silver powders was added to soluble varnish with a certain weight standard. Then, 30 teeth were divided into three groups for each time period (3 days and 1 month): nano silver-containing varnish, varnish, and without varnish (control group). For each sample, two class 5 cavities were prepared (one side of the buccal and lingual) with appropriate dimensions and optimum turbine and in each cavity (except to control) suitable varnish was applied and the cavities was filled with amalgam. Then, the teeth immersed in water for 3 days and 1 month depending on related groups. After the appropriate time has elapsed, the teeth were thermo-cycled. The teeth were placed in 2% Fushin. The teeth were divided into two halves from the middle of class 5 cavity. The sections were evaluated by stereomicroscope and dye penetration was measured. The data were analyzed by Two-Way ANOVA and Tukey multiple comparison test.Results: Tukey multiple comparison analysis showed that there was a significant difference between nano-silver containing varnish group and two other groups.Conclusion: Based on the results of this study, applying of nano-silver to varnish reduces microleakage in amalgam restoration.