EVALUATION OF THE PREVALENCE OF VACA AND CAGA IN PATIENTS WITH PEPTIC ULCER

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KHODAII ZOHREH; GHADERIAN SAYYED MOHAMMAD HOSSEIN; TABATABAEI PANAH AKRAM SADAT; AKBARZADEH NAJAR REZA

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Journal: DANESHVAR MEDICINE Year:2013 | Volume:20 | Issue:104 Page(s): 1-8

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Title

EVALUATION OF THE PREVALENCE OF VACA AND CAGA IN PATIENTS WITH PEPTIC ULCER

Author(s)

KHODAII ZOHREH | GHADERIAN SAYYED MOHAMMAD HOSSEIN | TABATABAEI PANAH AKRAM SADAT | AKBARZADEH NAJAR REZA | Issue Writer Certificate

Keywords

HELICOBACTER PYLORIQ3

CAGAQ1

VACAQ2

PEPTIC ULCERQ2

Abstract

gastrointestinal infections worldwide. Infection with H. pylori strains may results in different pathological manifestation and increased oxidative stress lead to a strong inflammatory response in gastric mucosa. There is continuing interest in identifying H. pylori virulence factors that might predict the risk for symptomatic clinical outcomes. The purpose of this study was to evaluate the prevalence of CAGA and VACA genes in patients with PEPTIC ULCER.Materials and Methods: The presence of IgG antibody against CAGA and VACA proteins was determined by using Western blotting technique. The presence of CAGA gene and VACA alleles was examined by PCR. H. pylori-positive patients including PUD and NUD were used for these experiments.Results: Biopsies were considered as H. pylori-positive and negative when both the rapid urease test and bacterial culture gave positive and negative results, respectively. H. pylori-positive, CAGA-positive, and VACA alleles (s1 and m2) were predominant in all clinical outcomes. There was no significant association between prevalence of CAGA and VACA status and clinical outcomes.Conclusion: Our results suggest that CAGA-positive strains were predominant in patients. However, we found no association between CAGA and VACA status and clinical outcomes and this virulence factor is not associated with the development of PUD. In addition, serological tests such as the western blotting are helpful in detecting subjects infected with H. pylori strains in PUD and NUD.

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APA: Copy

KHODAII, ZOHREH, GHADERIAN, SAYYED MOHAMMAD HOSSEIN, TABATABAEI PANAH, AKRAM SADAT, & AKBARZADEH NAJAR, REZA. (2013). EVALUATION OF THE PREVALENCE OF VACA AND CAGA IN PATIENTS WITH PEPTIC ULCER. DANESHVAR MEDICINE, 20(104), 1-8. SID. https://sid.ir/paper/30702/en

Vancouver: Copy

KHODAII ZOHREH, GHADERIAN SAYYED MOHAMMAD HOSSEIN, TABATABAEI PANAH AKRAM SADAT, AKBARZADEH NAJAR REZA. EVALUATION OF THE PREVALENCE OF VACA AND CAGA IN PATIENTS WITH PEPTIC ULCER. DANESHVAR MEDICINE[Internet]. 2013;20(104):1-8. Available from: https://sid.ir/paper/30702/en

IEEE: Copy

ZOHREH KHODAII, SAYYED MOHAMMAD HOSSEIN GHADERIAN, AKRAM SADAT TABATABAEI PANAH, and REZA AKBARZADEH NAJAR, “EVALUATION OF THE PREVALENCE OF VACA AND CAGA IN PATIENTS WITH PEPTIC ULCER,” DANESHVAR MEDICINE, vol. 20, no. 104, pp. 1–8, 2013, [Online]. Available: https://sid.ir/paper/30702/en

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