Before the establishment of Athens Science College, the most ancient foothold of scientific reflection was the philosophical and scientific boards of the Zoroastrian clergy (Moghs). The reports at hand prove that Greek thinkers and philosophers have enjoyed the springs of Persian knowledge in several ways. One of the oldest available sources to study the socio-intellectual conditions of Ancient Persia is Avesta; the ancient Persians’ scripture. Another proof to the centrality of the Persians, the Zoroastrian Clergy in particular, to the ancient knowledge is the accounts of ancient philosophers and historians, some of which are mentioned in the present article.It so appears that having learnt mathematics and astronomy from Babel as well as other neighboring countries, the Zoroastrian and/or the median Clergy launched a movement to develop the knowledge of time; then having stabilized the Persian worldview and philosophy, they launched another movement to transfer this knowledge to other nations. Under Achaemenians, Persia enjoyed great political, military, economic, and scientific power; hence it was powerful enough to transfer knowledge to other countries. In fact, Governors (Satraps) were the political and cultural representatives of Persia in other countries, who were usually accompanied by the clergy and/or the clerk (dabir). The two latter could successfully render the Persian thoughts and worldview to other nations. As a result, having developed in the East, i.e. in Persia, the popular Ancient knowledge, particularly philosophy, medicine, and astronomy was transferred to the West; after centuries, having become more developed, it returned to the East again.At the Islamic era, the Persians established many science centers, the most important of which was Beyt al-Hikmat (House of Knowledge) in Baghdad, where many scientific works from the languages of science, i.e. Sanskrit, Mid-Persian (Pahlavi), Syriac, and Greek were translated into Arabic; they also launched a movement to develop their contemporary knowledge; all of which was later yielded the West up. Nowadays the scholars of East and West unanimously acknowledge that the developed knowledge and Technology of the West is, no doubt, indebted to the scholars of the Islamic as well as other Eastern countries. Evidently, the Persians and their science centers, especially Gundishapour, have played an important role in the developmental trend of knowledge and sciences.