introduction: Life Expectancy (LE) at birth along with mortality rates, are considered as the key components of not only 'social determinants of health' but also as indicators of social, cultural, economic and health of societies. LE has become one of the indicators of health inequalities in any society, which is not usually assessed at the level of a single city area. Therefore, we aimed to estimate life expectancy and to evaluate the effects of social determinants of health (SOH) on it in different districts of Tehran as a metropolitan in 2008.Methods: This analytical cross-sectional study was performed during the year 2008 using the data from "Tehran Urban HEART Study". During August till November 2008, an approximate number of 1000families in each 22 districts of Tehran-totally 22492 households- including 81665 persons were recruited following cluster random stratification, of these 41585 were male and 40080 were female. A 13 pages questionnaire consists of several sections and detailed questions about demographic features, socioeconomic status, occupation, tenure, level of education, mortality, vaccination, violence, insurance coverage, household costs, was administered. Moreover, sufficient data on any mortality (including age and sex) in each household during the year 2008 was recorded. Life tables were extracted using Life Tab Excel software; also SPSS v.17and STATA v.10 were used to perform ecologic and concentration (individual level) analysis, respectively.Results: Overall life expectancy (LE) was calculated as 77.98 (95% CI: 75.50-78.69) yr which was significantly higher among women [79.96 (95% CI: 77.79-82.13) yr vs. 74.53 (95% CI: 72.2276.85) yr, P<0.05] than men. The highest LE was observed in the east (81.64 yr) and north (79.43 yr) of Tehran while the south region with LE of 74.38 yr had the lowest. Analytical procedures show that mortality was significantly more concentrated in families with lower total non-food costs (concentration index= -0.1599, P<0.0001) and lower level of education (concentration index=-0.1770, P<0.0001). Moreover, in ecologic data analysis, LE had significantly direct correlation with total non-food costs (r= +0.695, P<0.001), costs per capita (r= +0.553, P=0.009) and frequency of social class 1 or SC-1 (r= +0.437, P=0.030); while it was reversely correlated with family size (r=-0.486, P=0.025) and frequency of SC-5 (r=-0.476, P=0.029).Conclusion: Although the estimated life expectancy was higher in Tehran in comparison with the other estimations of the country, considerable differences were observed between regions and districts of this city. Socioeconomic status and the level of education were among the most important components of SDH that influenced mortality rates and LE in Tehran which were significantly different from a region to another one. Conclusively, geographical inequalities in mortality and socioeconomic status are shown to exist in Tehran area in this study, which emphasizes the need for urgent policy making in various disciplines including state ministries and Tehran municipality.