Feyz Medical Sciences Journal
Year:2005 | Volume:9 | Issue:3 (SERIAL 35)|Papers Count:11

Background: Diabetes, hypercholesterolemia and hypertension are three major risk factors that lead to the increased incidence of cardiovascular disease. Historically, there has been great interest in the role of garlic in reducing cardiovascular risk factors. In this study we evaluated effects of garlic tablet in type 2 diabetic patients with hyperlipidemia.Materials and method: A clinical trial (before and after) was performed in a group of 50 type 2 diabetic patients with hyperlipidemia (including 39 women, 11 men with serum cholesterol concentration greater than or equal to 220 mg/dl) to assess the effect of garlic powder tablet on blood glucose, lipid profiles and blood pressure. Each subject received tablets containing 300 mg of garlic powder (Garcin) 3 times per day jar 6 weeks. Before and after the treatment, blood pressure, fasting blood glucose, glycated hemoglobin and lipid profiles were measured. 24 hr dietary recalls were used to evaluate nutritional status of the patients.Results: Our results indicate that 6 weeks supplementation with garlic powder tablets give rise to a significant decrease in total cholesterol (p<0.01) and LDL-C (p<0.001) but increase in HDL-C (p < 0.02). We observed a considerable decreased in systolic blood pressure (p<0.03). There were no significant changes in diastolic blood pressure, fasting blood sugar. serum triglycerides and HbAlC. Also there were no significant changes in diet composition.Conclusion: 6 weeks treatment with garlic powder tablets significantly decreased total cholesterol, LDL-C, systolic blood pressure and increased HDL-C in type II diabetic patients with hyperlipidemia. Further studies are required to assess quality, efficacy and safety of this product.

Background & Objective: flatulence is the most common Postoperative gestational disorder and cesarean is the most common surgery in women that causes respiratory disorder, pain, the open the suture, and distention abdominal. Most drugs used to alleviate the abdominal flatulence are associated with Complications and harmful effects and give us a hint to adopt herbal medicinal. Materials & method: This clinical trial two-blined study, involving 124 women (Placebo 58 - drug 66) was be cesarean carried to evaluate the effect of super mint oil on flatulence intensity after cesarean in mobini hospitals in sabzevar. The method was eat drug and placebo after finished npo, three dose 40 drop per 20 mobini nutes in the have women that flatulence.Results: Mann - Whitney analysis results indicated a significant difference between two group in flatulence (second minute p=0.003, third minute p<0.001 and after 120 minute (p<0.001) had decreased. (P<0.001).Discussion: Therefore, the hypothesis "cumin oil is reducing on the flatulence intensity after cesarean section" was confirmed. Then proposed that cumin oil in flatulence after cesarean or any abdominal surgery was used.

Background: Neuropathic pain syndromes are changes resulted from damage to neuronal pathways which are characterized by spontaneous burning pain with accompanying allodynia and hyperalgesia. The mechanisms underlying neuropathic pain are poorly understood. The present study explores behavioral characteristics of the neuropathic pain models chronic constriction injury (CCI) and spared nerve injury (SNI).Materials and Methods: Experiments were performed on four groups (n= 8) of male Sprague-Dawley rats (230-280 g). Anesthesia was initially induced with sodium pentobarbital (i.p.) at a dose of 50 mg/kg. The CCI model was made by loose ligation of the sciatic nerve. Also a lesion of two of three terminal branches of the sciatic nerve leads to a SNI model. The animals were tested for behavioral responses cold-and mechanoallodynia and heat-and mechano-hyperalgesia. The cold and mechanical stimulations in the cold- and mechano-allodynia phenomena were applied through acetone and van Frey filament respectively. Pin-prick and radiant heat were applied as thermal and mechanical stimulations in the heat- and mechano-hyperalgesia respectively. Behavioral tests were conducted on the animals prior to surgery (the day 0), and 3, 7, 14, 21 and 28 days post-operation.Results: Our results indicate that, in comparison to the controlled group, the rats in both SNI and CCI groups reveal an obvious deference in behavioral responses. Although the SNI, compared to the CCI group were more sensitive to mechano-allodynia shortly after surgery (p<0.5); however, both groups share a similar pattern of behavior. In the heat-hyperalgesia testing, again, the animals in the CCI and SNI groups behaved differently than those in the controlled group, but no variation was evident among the test groups, themselves.Conclusion: These findings clearly show that the two neuropathic models produce abnormal pain-related disorders in the rats. A major feature of the SNI model was the very marked hypersensitivity to normally innocuous mechanical stimuli.

History and Objective: Ovarian hyper stimulation syndrome (OHSS) is a dangerous iatrogenic complication of ovulation induction cycles. Considering HCC injection complications, reports of GnRH agonist effectiveness and safety in other countries and no report in Iran, in order to determine GnRH agonist effect on ovulation induction cycles in OHSS risk, this study was performed in Mirza Koochak Khan Hospital in 5004-2000. Considering HCC's essential role in OHSS, in ovulation induction cycles with many follicle number and estradiol level elevation, HCC injection is not recommended. GnRH agonist was used for final oocyte maturation and ovulation stimulation; in order to inhibit OHSS risk and Material and Methods: A clinical trial was performed on women in ovulation induction cycle combined with IUI that were in OHSS risk. Patients were randomized in case and control group. Case group received GnRH agonist and the control group didn't. Progesterone level was measured on 21 st or 23rd day of period cycle and was followed for ovulation, pregnancy and OHSS.Results: 34 patients of total 70 that had suitable conditions were studied. Patients were matched for age and estradiol level. Ovulation rate in case and control group was 50% and 74/1%, respectively that was not statistically significant. There was no case of OHSS in both groups.Conclusions and Recommendations: Results have revealed that GnRH agonist injection in hyper stimulated cycles will be successful and prevent OHSS. Therefore its application is recommended.

Background: Trichostrongyliases as zoonotic diseases are of major public health and sodo-economic importance. Accurate identification of these parasites is the first step in strategic planning for the prevention, control and treatment of the parasitic disease. The aim of this study is using PCR-RFLP technique for genotyping.Materials and methods: samples were collected from elementary tract content of 70 sheep in lsfahan and Khorasgan slaughterhouses. Identification of Trichostrongylus was determined based on morphological character and key identification after direct and flotation methods. For genotyping studies, DNA was extracted and the ITS-2 of ribosomal DNA of each species with specific primers was amplified by PCR and restricted with the endonucleases DraI, RsaI, HinfI. The profile was visualized in agarose gel under ultraviolet transillumination.Results: The eggs of most species are morphologically indistinguishable at the generic level .rDNA-ITS2 fragment size of all species were the same size about 330bp, however, there were differences among species in their PCR-RFLP patterns. The two fragments produced with Rsal in all species were the same size about 138bp, 190bp. The PCR product Tprobulurus with Dral remained unrestricted. Restriction with Dral produced two fragments in the PCR product of Taxei and Tcolubriformis about 110bp, 215bp, however, the larger of the two fragments in T.vitrinus is smaller in size than in Taxei and T.colubrtformis had a size about 145bp, 185bp. The two fragments produced with HinfI in T.colubriformis had a size about 90bp, 238bp, By contrast other Trichostrongylus remained unrestricted.Conclusion: Based of our results from genotyping studies using PCR-RFLP technique, it can be concluded that four species had been identified. This study provides a pattern to distinguish Trichostrongylus species in Isfahan region using the DraI, RsaI HinfI restriction endonucleases.

Backgrounds & Purpose: Ramadan fasting is a unique cycle in which man should avoid eating and drinking. In many conditions such as plasma LDL and IGF-1 concentration, effects of prolonged & Ramadan fasting are different. This study was conducted to determine the effect of Ramadan fasting on LDL & IGF-1 and their correlations.Material & Methods: 132 healthy adult volunteers (60 women, 72 men) took part in this quasi-experimental study. All participants fasted for at least 25 days in the lunar month of Ramadan. The amount of serum IGF-1 was measured by radioimmunoassay 1 week before and on the 14th and 28th days of Ramadan. Statistical analysis with ANOVA, the Student's paired Hest, and Pearson's regression analysis were all carried out in this respect.Results: No significant change in the serum concentration of IGF-1 was found in men, women or the group during this study, but serum level of LDL was decreased significantly.Conclusions: Ramadan fasting has no effect on plasma IGF-1, but it decreases plasma LDL significantly.

History and Objective: Due to the important different prevalence of Gastrointestinal tract parasites in domestic animals and lack of information of Gastrointestinal parasites in ruminant in Kashan, the present study was conducted in 2002 to determined the prevalence of Gastrointestinal Trichostrogylus in sheep and goats in slaughterhouse of Kashan.Materials and Methods: A descriptive study was carried out on the digestive tract of 158 sheep and goats from of different area of Kashan.Results: The rate of infection in sheep and goats was 87.5% and 83.3%. The smallest intestinal infection in sheep and goats was Nematodirus oiratianus 73.7% and 64%. In the abomasa parasite of sheep and goats was Marshallagia marshalli 80% and 83%. In the all cases females were more frequently infected than males.Conclusions: Due to the relatively high prevalence of Trichostrogylus in domestic animals we suggest further studies to determine the causes this problem and find methods to prevention those infected.

History and Objective: Human hydatid disease has been world widely spread and its frequency clinical presentation, diagnostic methods, treatment and recurrence rate were reported variously. For determining the frequency, surgical results, and recurrence rate, this study was performed in Kashan area.Material and Methods: A cross-sectional study on patients with hydatid disease was caried out. Age, sex, living side, clinical loboratory, imaging finding, anatomic location and operation procedure, were all considered. At the end of the investigation for recurrency, chest X-rey pA Ultra sonography of abdomen and indirect hemagglotination test IHT was performed.Finding: From 135 cases (62.2%) were female, FM/M-1.6/1 the incidence pick was in (2-30).58. % living in rural area 68% of cyst was in abdomen (liver) and 30% pulmonary, caught and then sputum was the most frequent symptom in pulmonary hydatid disease, abdominal pain and fever in liver hydatid disease was more frequent.Casoni test in 85.3% pre-operation was positive and indirect hemagglotination test IHT serology after 5years 90% was positive Diagnosis of liver cyst was confirmed by ultra sonography in 98% in lung with chest X ray and CT scan 88.9 and 100% respectively. The most common procedure in liver was cystectomy and omentoplasy, in lung was systectomy.We did not use any scolocidall agent and had 4 patients recurrence in liver 3% but no any patient had pulmonary Recurrent indirect hemagglotination test IHT after 5years operation in 88.4 was positive.Conclusion: It seems that after perfect surgery no scolocidal drug administration is necessary and indirect hemagglotination test IHT is an excellent sero diagnostic means.

Objectives: One of the main goals of establishment of radiology technology discipline is training students who can imagine high-quality radiographic perspective. For this reason students must study theoretical basis of imaging techniques at first and then follow this principle in lab and finally apply them on patients. At present, in our country the second stage of this process (taking an image in lab) doesn't take place because of some restrictions such as radiographic phantoms. This matter causes some problems. The Aim of this study was construction of teaching radiographic phantoms to train students to get radiographic image in lab. After lab training, they enter into radiology departments (real environment).Methods and material: Natural bone from anatomy department was provided and then adjusted with respect to its anatomical position in body and various radiographic positions. Simultaneously from each region a mold was prepared and bones set in correct anatomical and radiographic position into that and then it was filled with melted paraffin. After cooling the phantoms they were taken took out and colored.Results: Investigation and comparison of results showed that instructed phantoms have very similarity with patient radiographs with regard to physical parameters such as density and contrast.Conclusion: This result showed that construction of radiographic teaching phantoms is possible in our country and according to their quality we can use them in training of students.

Background: Considering chronic nature of multiple sclerosis (MS), it is necessary to utilize appropriate methods in order to improve coping in MS patients. So, this study was conducted on patients with MS supported by the Iranian MS Society in 2001 for determining the effect of self - care program on their Applying coping mechanism.Materials & Methods: In this semi - experimental study 34 patients with MS who were not in the acute phase of disease were selected. The data was collected via personal questionnaires. Problem list, jalowice standard coping scale and self report check lists.The validity of jalowice coping scale was approved in Iran and the Reability of questionnaires was then approved using a pilot study on the first 10 samples revealing a high correlation coefficient (r=0.87). Self care program (self – care for muscular spasm, fatigue, constipation and amnesia and...) was educated. Then self - care program was performed for one month period and the data was analyzed using paired t- test, wilcoxon. croscal - wallis and manwithney tests.Results: Application of self - care program reduced applying affective -focused coping and reduced some symptoms such as muscular spasm fatigue, constipation and amnesia in MS patients. The, mean valve of affective -focused coping reduced from 81/61 before performing the program to 64 after the program (p<0.05).Conclusion: Self-care program can be an effective method for reducing applying affective -focused coping of MS patients.

Background: Considering the adverse effects and difficulties due to formula feeding or early commencement of supplemental diet and also different reports from their status, this study was conducted to investigate the nutritional status and related factors in 4/5 month-old infants referred to health care centers in kashan in 2002.Materials and methods: This cross - sectional study was performed on 350 mothers who had children aged 4/5 months. The sampling was done randomly in several phases. The information about kinds of diet, maternal age, maternal education, occupational status, infant sex, order of infant's birth, the commencement time of first feeding, exclusive breast feeding period and the commencement time of supplemental diet were collected. Also the weight and height of infants were measured. Then the collected data was analyzed.Findings: Non exclusive breastfeeding was observed in 17.7% of infants and in 3.7% of them, supplemental diet had begun earlier than their 4-month age. Breast feeding period in 82.3% of infants was more than 4 months. There was a statistically significant correlation between kinds of diet and maternal age (P<0.002), occupational status (p<0.001) and the commencement time of first feeding (p<0.0005). Infant weight in exclusive breastfeeding group (N1= 288) was 7243 ±792.1 gr and in non exclusive breast feeding group (N2=62) was 6891±1059 gr (P<0.002). Their height was respectively 62.63±2.9 cm and 62.25±3.1 cm (P<0.1).Conclusion: Early beginning of breastfeeding in postpartum period, paying further attention to old mothers and employed mothers have an important role in exclusive breastfeeding development and prevention of infant mortality.