Introduction: Climate affects, more than any other factors, the type and form of human life, so that many cities that have made or developed regardless of climatic information are suffering from weather-related problems such as air pollution, water supply and flooding etc. By using the meteorological information in designing new cities as well as developing old cities can reduce the mentioned problems. Human comfort condition, based on the definition, is a thermal condition that is comfortable for at least 80% of people. Regarding the high impact of climate on human comfort, the humankind has been always looking for a suitable usage of the local climate. It was investigated the effective bioclimatic indices over human comfort in Shiraz city and their results showed that Shiraz with having a various bioclimatic condition holds a warm to very cold climatic conditions throughout the year. Attempt was made to study the climatic comfort index in Boushehr city. His findings from THI index indicated that the months of April, May, November, December, January, February and March are appropriate in terms of climate comfort for human. Investigation on the thermal comfort was made in Shahrud-Semnan from military viewpoint. In addition, the effect of climate on the architecture of Qom city was carried out by attempted to classify the climate based on effective parameters on life quality in Markazi province. Therefore, considering the high impact of climate on the human comfort as well as the spread of urbanization, in this research this subject is studied in the megalopolis city of Tehran.