Background and Objectives: Researchers and health specialists are increasingly using self-reports to obtain information on chronic illnesses. This study was conducted to assess the validity of self-reports of diabetes based on a recent field survey in Mashhad. Methods: In this cross-sectional study, we used the results of 2015 census in Mashhad, a population based survey of people over the age of 30 (n =307103), to determine the proportion of self-reported diabetes. The patient records of Sina Electronic Health Record system (SinaEHR® ) coded as E11 and E12 approved by doctors were used as a reference. The sensitivity, specificity, positive predictive value, and negative predictive value were calculated with 95% confidence intervals. Results: The sensitivity, specificity, PLR, NLR, PPV, and NPV of self-reported diabetes was 24. 59% (95% CI: 23. 97-25. 21), 98. 04% (95% CI: 97. 99-98. 09), 12. 56% (95% CI: 12. 11-13. 02), 0. 77% (95% CI: 0. 76-0. 78), 44. 77% (95% CI: 43. 89-45. 67), and 95. 27% (95% CI: 95. 23-95. 31), respectively. The sensitivity of selfreported diabetes was higher in men, Iranian individuals, single subjects, people aged 60 and over, individuals with a BMI of 18. 5-25, and those with university education. Conclusion: Although the sensitivity of self-reported diabetes was poor in this study, its specificity and positive and negative predictive values were good. Furthermore, the sensitivity of self-reported diabetes was higher in men, Iranian individuals, single subjects, people aged 60 and over, individuals with a BMI of 18. 5-25, and those with university education. It seems that caution should be exercised in using self-reported data in epidemiological studies.