Background and Aim: Water quality monitoring in rivers is very important for deciding on their water use. Thus, this study was conducted to evaluate rivers’ water quality in Khuzestan province. Materials and Methods: The rivers studied included Dez, Karkheh, Marun, Karun, and Zohreh. Data were collected in 2018 from specified stations in each river. The water quality standards of Iran, WHO, and the Canadian Council of Ministers of the Environment, as well as Schoeller and Wilcox diagrams, were used. Besides, IRWQIsc and NSFWQI standards were employed to categorize the river water quality. Results: The results showed that Dez river water was corrosive for industrial use, while other rivers had scaling water for industrial use. The quality of Dez river water was better than that of other rivers in Khuzestan province, but this river had high magnesium, hardness, and chloride based on the Schoeller diagram. The water quality of this river was better than others’ water quality for use in agricultural purposes. Karun river was moderately better than other rivers, and the water quality was better in the upstream than in the downstream. According to IRWQIsc, the water quality variations in Dez, Karkheh, Karun, Marun, and Zohreh rivers were 71-83, 41-52, 39-55, 33-41, and 25-32, respectively. The results of the NSFWQI index for Dez, Karkheh, Karun, Marun, and Zohreh rivers showed that the values of these rivers varied in the ranges of 65-77, 55-70, 58-68, 52-60, and 36-48, respectively. Conclusion: Dez river was in a relatively good condition. Karun and Karkheh rivers were in a moderate condition and other rivers were in a relatively poor condition. According to all indices, the water quality of the Zohreh river had poor conditions and Dez river water was in a good condition. Other rivers had moderate water quality.