In the present, study the performance of a single-stage cylindrical electrostatic precipitator for separation of gypsum and salt particles in the air was experimentally investigated. The average diameter of salt and gypsum particles are 198 and 290 nm, respectively. The effect of structural properties, i. e., particle size and specific electrical resistance and operating conditions, i. e., voltage, the diameter of discharge electrode, air velocity, and electric current on the collection efficiency were investigated. Results show that the collection efficiency for gypsum particles is more than that of the salt particles. In the voltage range of 6 to 10 kV, sparks didn’ t occur so, by increasing the voltage obtaining higher values of efficiency is possible. The decrease in efficiency by an increase in air velocity for gypsum particles is higher than that of salt particles, which show that for salt particles operation at higher flow rates is economically possible. Optimum collection efficiencies of gypsum particles at gas velocities of 1. 2 and 2 m/s were determined by response surface method to be 88. 6% and 60%, respectively. Corresponding values for salt particles are 72. 8% and 68%, respectively. experimental results verified these values.