IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)
Year:2018 | Volume:20 | Issue:2|Papers Count:5

Introduction: Few studies have investigated the interaction of food patterns with polymorphisms of the MC4R, ZNT8, and CCND2 genes. This study was performed to evaluate the interaction between MC4R rs12970134, ZNT8 rs13266634 and CCND2 rs11063069, polymorphisms and dietary patterns, in relation to MetS. Materials and Methods: A total of 1630 subjects were selected from participants of the Tehran Lipid and Glucose Study. The cases and controls were matched by age, gender and the years of follow-up. Dietary intakes were obtained using a valid and reliable semiquantitative food frequency questionnaire. Dietary patterns were determined using factor analysis on 25 food groups. MC4R rs12970134 and ZNT8 rs13266634 polymorphisms were genotyped by Tetra-Primer ARMS-PCR Analysis, and CCND2 rs11063069 by the ARMS-PCR Analysis. Results: The mean ages were 43. 3± 11 and 43. 03± 12 years in cases and controls, respectively. Two healthy and western dietary patterns were identified. MetS risk increased in the fourth quartile of western dietary pattern scores, in A allele carriers of rs12970134 (OR: 1. 71 (1. 04-2. 41), compared to other genotypes. This risk decreased in the fourth quartile of healthy dietary pattern scores in G allele carriers of rs11063069 (OR: 0. 88(0. 39-1. 78), P trend<0. 01). However, this trend was not observed in the AA genotype of rs11063069. Conclusion: According to the results of this study, adherence to healthy or western food patterns could respectively alter the effects of 12970134rs and 11063069rs polymorphisms, on the development of metabolic syndrome.

Introduction: Brain-Derived Neurotrophic Factor (BDNF), besides its major role in behavioral disorders, plays an important role in controlling food intake and weight. The combined effects of exercise and diet on BDNF levels, have not been completely identified. Therefore, the current study was aimed to investigate the effect of acute aerobic exercise following different diets, on serum levels of BDNF and Cortisol in overweight men. Materials and Methods: In this quasi-experimental crossover study, 10 overweight men (23± 6. 1 years old and 29. 26± 0. 47 BMI), attended our physiology lab, in 4 sessions with one week intervals. In each session, after consuming Normal (N), High-carbohydrate (HCHO), High-protein (HP) and High-fat (HF) diets, the subjects performed a 30 min treadmill aerobic exercise, with 60-70% of maximum heart rate, and furthermore, blood samples were taken to measure serum levels of BDNF and Cortisol at fasting, 2 hour after the diet (before exercise), and after exercise. Results: Serum levels of BDNF showed a significant increase after acute aerobic exercise, following HCHO (P=0. 001), HP (P=0. 001) and N (P=0. 039) diets compared to the HF diet. There was no significant difference in serum levels of cortisol after aerobic exercise, following the 4 different diets (P=0. 258). Conclusion: It seems that calorie intake from the HF diet, reduces serum levels of BDNF in overweight men, and aerobic exercise after consuming this diet, despite the lack of changes in Cortisol levels, does not increase BDNF levels.

Introduction: Adropin plays an important role in lipid metabolism; however, no research seems to have been done on the effect of exercise on serum adropin levels. Therefore, the present study attempted to investigate the effect of an aerobic exercise session with FATmax intensity on adropin levels and insulin resistance among overweight women. Materials and Methods: The participants, who volunteered to take part in the research through announcements, included 24 overweight women with the means and standard deviations of their age, height, and weight being 25. 34± 4. 1 y, 163. 6± 4. 07 cm, and 76. 94± 4. 56 kg, respectively. The exercise group performed an acute endurance activity, while the control group rested for the same amount of time. In an acute endurance activity session, the participants ran on treadmills for 30 minutes at their FATmax intensities. Changes in the data for the two groups were calculated, before and after the activity session and then compared using independent-samples t-tests. The significance level for all the statistical analyses was set at p<0. 05. Results: Results showed significant differences between the two groups in terms of insulin (p=0. 030) and insulin resistance (p=0. 031), but not such a difference for glucose (p=0. 327) and adropin (p=0. 330). Conclusion: It seems that this type of activity, despite its largely aerobic nature, simply failed to stimulate adropin, due to the effect of the control group’ s fasting state on increasing adropin levels, and/or the lower duration and intensity of the activity.

Introduction: The aim of the current study was to systematically review studies on the associations of obesity or body mass index (BMI) with anti-mullerian hormone (AMH). Materials and Methods: PubMed and Scopus databases were searched using the appropriate keywords. Original studies published up to December 2016, that evaluated the independent associations of BMI or obesity with AMH in reproductive aged women, were considered eligible. Results: In this study, 26 articles were included. Based on Polycystic ovarian syndrome (PCOS) and fertility status, participants were divided into three groups of PCOS women, infertile non-PCOS women, and fertile and non-PCOS women. Seven of 11 studies on PCOS, 3 of 7 studies on infertile and 4 of 5 studies on non-PCOS women, reported negative correlations between BMI and AMH. However, strength of the correlations were weak (mostly less than 0. 3). Four out of 6 studies on PCOS women, 1 out of 3 on infertile women, and 2 out of the 7 on fertile non-PCOS women reported a significant lower AMH level in obese than in non-obese women. Conclusion: The association between BMI and ovarian reserve is not clear according to the current findings.