Introduction: A low level of health literacy is common among patients with Type 2 diabetes, and may be a barrier to self-efficacy and self-care behaviors, The purpose of the current study was to examine the relationship between health literacy, and self-care and self-efficacy in Patients with Type 2 diabetes, Materials and Methods: A cross-sectional analytical study was conducted in 2017, Participants were type 2 diabetes patients from the rural health clinics in khorramshahr city, of which 121 were selected via random cluster sampling methods, Data collection tools were a health literacy scale (14-items), self-care scale (12 items) and self-efficacy scale (8 items), Data were analyzed using the SPSS software version 22, and by Pearson’ s correlation, T-test, ANOVA, and Stepwise Regression analytical statistics, Results: The mean scores of health literacy, selfcare and self-efficacy in patients were 2, 90± 0, 53, 3, 39± 1, 31 and 6, 77± 1, 80, respectively, Pearson correlations indicated a positive relationship between health literacy, and both self-care and selfefficacy (P<0, 0001 for both), Conclusion: Designing a curriculum for diabetes patients with low health literacy is required, and improving their information and health literacy, through a curriculum and regular training programs in health education centers is recommended,