Background and Aims Heart disease can affect patients and their families, and society's biopsychological status. Thus, it is necessary to empower patients to better control the disease and improve their lives. The current study evaluated the effect of empowerment program based on the health belief model on perceived satisfaction in patients with acute coronary syndrome. Methods This clinical trial study was conducted on 70 patients with acute coronary syndrome who were randomly assigned to two intervention and control groups. Initially, perceived satisfaction questionnaires were completed in the two groups; then, the intervention group received a 7-session empowerment program based on the health belief model, and usual care was provided to the controls. Immediately, one month, and three months later, the questionnaire was completed by the two groups. The obtained data were analyzed using the Mann-Whitney U test, Wilcoxon test, and Chi-squared test in SPSS. Results The two groups were matched in terms of demographic variables such as gender, age, and the type and duration of disease (P>0. 05). Comparing the level of changes in perceived satisfaction in the two groups revealed that posttest changes were significantly higher in the intervention group, compared to the controls (P<0. 001). The mean± SD pretest, immediately after and one month, and three months after the intervention scores of perceived satisfaction changes in the test group were 116. 36± 33. 88, 154. 1± 29. 07, 144. 3± 27. 32, and 127. 2± 28. 58, respectively. Conclusion According to the obtained results, implementing the empowerment program based on the health belief model can increase perceived satisfaction in patients with acute coronary syndrome.