Introduction: Water-vapor is an essential climate element. Through latent heat exchanges, the water vapor is considered as the principal way of energy transport through the global atmosphere and it is also a dominant greenhouse gas (Held and Soden, 2000). Over the oceans, warmer surface temperatures may lead to increased evaporation and, therefore, greater specific humidity, but an approximately constant relative humidity (RH); the greater concentration of water vapor will, in turn, warm the surface further, since water vapor is a potent greenhouse gas (GHG) OPCC, 2007; Dessler and Sherwood, 2009). As temperature rises, the atmosphere's capacity to hold water vapor is also increased. As the water vapor can be transported vertically through convection and subsidence, and horizontally by atmospheric circulation, changes in surface absolute moisture can cause changes in moisture aloft (McCarthy and Toumi, 2004). The Clausius-Clapeyron relation represents exponential increases in the atmosphere's water holding capacity with increasing T at approximately 7% K-1 (Manabe and Wetherald, 1967; Allen and Ingram, 2002; Trenberth et al., 2005). Knowledge about changes in water vapor in the upper troposphere and lower stratosphere is important because it can result in strong alterations in radiative forcing, hydrological cycle, precipitation intensity, human activities and biosphere. The aim of this study is to analyze spatiotemporal variation of atmospheric humidity of Iran during 1979-2013.