Introduction: The present study aimed to compare the effectiveness of mobile social networkbased mindfulness interventions, acceptance and commitment therapy, and mindfulness group therapy on depression, anxiety, and stress in patients with type II diabetes mellitus. Materials and Methods: This quasi-experimental study was conducted on 80 type II diabetic patients, referring to the diabetes treatment centers of Isfahan, Iran, in the spring of 2018, using a pretest-posttest control group design with a 3-month follow-up. The study population was selected using purposive sampling technique based on the inclusion criteria, and then randomly assigned into three experimental groups and one control group. The DASS-21 questionnaire was used to measure depression, anxiety, and stress. The mindfulness group interventions and acceptance and commitment group therapy were conducted in eight 120-minutes sessions. In addition, the mobile social network-based mindfulness interventions were performed in 45-minute sessions every night for 8 weeks, except for holidays. The data were analyzed using repeated measures ANOVA with Bonferroni post hoc test using SPSS software (version 23). Results: According to the results, all three types of treatments had a significant effect on the improvement of psychological symptoms in diabetic patients. There was a significant difference among the social networking mindfulness interventions, acceptance and commitment therapy (ACT) and mindfulness therapy in the reduction of depression (P=0. 001), anxiety (P=0. 001), and stress (P=0. 001) among patients with type II diabetes mellitus. Conclusion: Based on the findings, the use of mobile social network-based mindfulness interventions for patients who cannot participate in psychological treatment group meetings can be used as an effective intervention for the treatment of psychological symptoms, depression, anxiety, and stress in diabetic patients.