Journal of Jiroft University of Medical Sciences
Year:2021 | Volume:8 | Issue:1|Papers Count:8

Introduction: Thyroid hormones are one of the most important hormones affecting the body's metabolic function, so the treatment of hormonal disorders of this gland using low-risk drugs and methods such as exercise and herbal remedies is effective. Hence, the purpose of this study was to evaluate the effect. Interactive exercise and aniseed extract of Anvillea garcinii extract on Cholesterol and thyroid hormones in hypercholesterolemia rats. Materials and Methods: This study is of experimental type and 40 male Wistar rats randomly were divided into five groups of eight, including healthy control group (Con), control hypercholesterolemia (Hc), anvil extract at a dose of 100 mg/kg, (Ext), training group (E ), Extract-exercise (E-Ext). Endurance exercise was performed for 8 weeks, 30 minutes and three sessions per week at a speed equivalent to 1417 m/min. Then, the amount of biochemical factors including cholesterol, TSH, T3 and T4 was sampled and measured by the kit in order to determine the differences between groups ANOVA test used. Results: The results showed that the difference between the mean levels of cholesterol (p<0. 0001), T4, T3 and TSH (p<0. 0001) between the groups was significant. The results of Tukey post hoc test showed, the difference between cholesterol level in the extract-exercise group compared to the control of hypercholesterolemia (p<0. 001) and extract (p<0. 05) was also significant compared to the control group of hypercholesterolemia (p<0. 008). Difference between T4 level in the extract group-exercise compared to hypercholesterolemia control, extract and exercise (p<0. 001) and T3 level in the extract group exercise compared to hypercholesterolemia control (p<0. 05), extract (p<0. 0001) and exercise (p<0. 05) were significant. The amount of TSH in the extract group of exercise compared to the control of hypercholesterolemia (p<0. 001), extract (p<0. 001) and exercise (p<0. 05) and also the exercise group in relation to the extract (p<0. 05) a significant increase was observed. Conclusion: Consumption of plant extracts along with exercise have the best effect on cholesterol and thyroid hormones levels.

Introduction: The prevalence of Allergy Rhinitis (AR) has increased dramatically among children. The aim of this study was to determine the prevalence of AR symptoms among school‐ age children in Zahedan, southeast of Iran. Materials and Methods: In this cross-sectional study, 1600 primary school girls and boys were selected and examined by multistage random sampling. Data were collected and completed using the International ISAAC (International Study of Asthma and Allergies in Childhood) questionnaire including demographic questions and risk factors through interviews with parents, especially the student's mother. The data were analyzed in SPSS19 software using chi-square test and multiple logistic regression. Results: The prevalence of current AR and Rhinoconjunctivitis among elementary school Children was 15. 3% and 10. 2% respectively. The prevalence of current AR was not statistically significant in girls with 14. 2% and boys with 16. 4% (p>0. 05). Co-morbidity with asthma and eczema was 27. 3% and 28%, respectively. The occurrence of AR was related to BMI, family size, snoring father, type of heating and cooking (p<0. 05). Conclusion: The prevalence of AR in Zahedan is relatively high due to the special climatic conditions and geographical climate of the region. Overweight in students and the use of fire for cooking and heating the house is an effective factor in the prevalence of AR in children, which can be eliminated by reducing the prevalence of this disease. However, the mothers have most important role in screening and early diagnosis of AR in school children regarding determinants in this study.

Introduction: Obesity, sedentary, and vitamin D deficiency are closely linked to diabetes. The aim of this study was to determine the effect of eight weeks of aerobic exercise on plasma levels of vitamin D and glycemic control indicators in type 2 diabetic patients. Materials and Methods: From among males with type 2 diabetes, 24 patients with mean age (49. 5± 0. 81 years) and BMI (29. 6± 1. 3 kg/m 2 ) were randomly divided into two groups including aerobic exercise (n=12) and control (12 people). The aerobic exercise program was performed for eight weeks with an intensity of 50 to 75% of the heart rate reserve. Levels of vitamin D, HbA1c, glucose, insulin, insulin resistance, insulin sensitivity and beta cell function were measured in the pretest and posttest. Dependent ttest and analysis of covariance were used for intragroup and intergroup comparison and Pearson correlation test was used for the measurement of variables relationship. Results: The results showed that the percentage of HbA1c, glucose, insulin and insulin resistance in the aerobic exercise group had a significant decrease compared to the control group (p<0. 05), However, vitamin D levels, insulin sensitivity and beta cell function in the aerobic exercise group increased significantly compared to the control group (p<0. 05). In addition, the results of Pearson correlation test showed a significant relationship between vitamin D levels and glycemic control indicators in the aerobic exercise group (p<0. 05). Conclusion: In this study, it was observed that aerobic exercise is an effective strategy to improve glycemic control indicator in type 2 diabetic patients. This supportive effect is probably related to the development of plasma levels of vitamin D.

Introduction: The inability of chemical drugs to completely treat patients with colon cancer has made itone of the deadliest cancers in the world in both sexes. Medicinal plants are important elements of the indigenous medical system. Many plant compounds are currently being developed as potent anticanceragents. However, some anticancer agents are still extracted from plants because they have complexstructures that cannot be chemically synthesized on a commercial scale. The aim of this study was toevaluate the effects of Moringa hydroalcoholic extract on colon cancer. Materials and Methods: Moringa leaves were purchased and approved, and then its hydroalcoholic extract was extracted. The total phenolic and flavonoid content of the extract was measured, and then the dominant phenolic and flavonoid compounds of the extract were confirmed by HPLC method. The antioxidant power of the extract was measured. Then, the toxic effects of the extract on colon cancer cellviability (CACO2) were investigated by MTT assay. After tumor induction in mice, tumor volume wasassessed after extract injection. Results: The flavonoids with antioxidant properties identified in this study included quercetin, gallic acidand caffeic acid. MTT results showed that Moringa at a dose of 1024 μ M could not kill 50% of CACO2cells, but by injecting it into the tumor, it had positive effects on reducing tumor volume. The effects of theextract on the tumor were dose and time dependent. Conclusion: Moringa extract with different flavonoids can be used as a useful plant source in the treatment of colon cancer.

Introduction: Type 2 diabetes is considered as a risk factor for heart disease and has a major contribution to death and mortality due to cardiovascular disease. The aim of this study was to evaluate the effect of a continuous aerobic training period on the expression of VEGFA protein and expression of eNOS gene and VEGFR1 / 2 receptors in cardiocytes of type 2 diabetic rats. Materials and Methods: 18 rats were randomly divided into 3 groups of 6 including healthy control, diabetic control, and continuous aerobic exercise. After an 8-week training period, the expression of eNOS VEGFR1 and VEGFR2 genes and VEGFA protein in left ventricular cardiomyocytes of rats was evaluated by RealTime-PCR and Western Blot techniques, respectively. Insulin level, glucose level and insulin resistance index were measured. To determine the significance of the differences between the research groups, one-way ANOVA statistical test was used at the significance level of p= 0. 05. Results: The results showed that there was a significant difference (p<0. 05) between the VEGFA protein expression and the continuous aerobic exercise control group. There was a significant difference in the expression of eNOS gene between the two groups of continuous training with diabetic control (p<0. 05), the values of changes in VEGFR1 gene expression were positively and incrementally adjusted compared to the diabetic training group. There was also a significant difference between insulin, glucose and insulin resistance levels in the training group compared to the control group (p<0. 05). Conclusion: It seems that the 8 weeks of continuous aerobic exercise training on the expression of VEGFA protein and expression of eNOS gene and tyrosine kinase receptor genes in the cardiocytes of diabetic rats is effective and can probably be considered as an effective intervention method.

Introduction: Psychological hardiness is a personality structure that is considered as a source of resistance to medical students in stressful situations. The aim of this study was to determine the role of spiritual intelligence and identity styles in predicting psychological hardiness of students of Kerman University of Medical Sciences. Materials and Methods: In this cross-sectional descriptive study, 300 students of Kerman University of Medical Sciences included in the study by random cluster sampling. Data collection instruments in this study were demographic information questionnaire, hardiness questionnaire, identity style and spiritual intelligence. Pearson correlation, independent t-test, Kruskal-Wallis, analysis of variance and linear regression were used to analyze the data. Results: The mean score of psychological hardiness in research units was 48. 16± 9. 68, spiritual intelligence was 10. 43± 18. 62 and identity styles were 128. 01± 15. 99. The results showed that the variables of spiritual intelligence and types of identity styles as independent variables had the predictability of psychological toughness as a dependent variable (r = 0. 41, p<0. 001). Conclusion: The results of this study showed that spiritual intelligence and identity styles have a positive effect on psychological hardiness. Promoting and improving spiritual intelligence and identity styles increases students' psychological hardiness. Therefore, increasing psychological hardiness can be a factor to improve students' mental health.

Introduction: Diabetes mellitus is the most common metabolic disorder which according to some research, is the most common endocrine disease and a threat to global health. However, many people with diabetes insist on fasting. Materials and Methods: This study was conducted with a cohort of 94 insulin-treated type 2 diabetic patients in the low to moderate risk group for 3 months. These patients were divided into two groups, including43 fasting patients and 51 non-fasting patients. Finally, data were analyzed through SPSS software version 22. In order to describe the variables, two types of statistical procedures, namely independent and paired t-test or their non-parametric equivalents were used. Results: It was indicated that there was a statistically significant difference in Weight, triglyceride (p<0. 05), high-density lipoprotein (p<0. 01), low-density lipoprotein (p<0. 05) and concentrated lipoprotein (p<0. 05) between the two groups. Separation study of the studied groups showed that weight gain, triglycerides, LDL, VLDL and total cholesterol in the control group were the cause of the above changes and only LDL significantly decreased and HDL significantly increased (p≤ 0. 05). Conclusion: Fasting with a regular diet and an exercise program during Ramadan, even in diabetic patients treated with premixed insulin, has a beneficial effect on lipid and lipoprotein factors.