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Information Journal Paper

Title

The effect of hydroalcoholic extract of Moringa oleifera leaves in a mouse model of colon cancer induced by CACO2 cell line

Pages

  574-585

Abstract

 Introduction: The inability of chemical drugs to completely treat patients with Colon Cancer has made itone of the deadliest cancers in the world in both sexes. Medicinal plants are important elements of the indigenous medical system. Many plant compounds are currently being developed as potent anticanceragents. However, some anticancer agents are still extracted from plants because they have complexstructures that cannot be chemically synthesized on a commercial scale. The aim of this study was toevaluate the effects of Moringa hydroalcoholic extract on Colon Cancer. Materials and Methods: Moringa leaves were purchased and approved, and then its hydroalcoholic extract was extracted. The total phenolic and flavonoid content of the extract was measured, and then the dominant phenolic and flavonoid compounds of the extract were confirmed by HPLC method. The Antioxidant power of the extract was measured. Then, the toxic effects of the extract on Colon Cancer cellviability (CACO2) were investigated by MTT assay. After tumor induction in mice, tumor volume wasassessed after extract injection. Results: The flavonoids with Antioxidant properties identified in this study included quercetin, gallic acidand caffeic acid. MTT results showed that Moringa at a dose of 1024 μ M could not kill 50% of CACO2cells, but by injecting it into the tumor, it had positive effects on reducing tumor volume. The effects of theextract on the tumor were dose and time dependent. Conclusion: Moringa extract with different flavonoids can be used as a useful plant source in the treatment of Colon Cancer.

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    APA: Copy

    Balouchi, Adeleh, FAZILATI, MOHAMMAD, HABIBOLLAHI, SAEED, NAZEM, HABIBOLLAH, & Hejazi, Seyed Mohammad Hossein. (2021). The effect of hydroalcoholic extract of Moringa oleifera leaves in a mouse model of colon cancer induced by CACO2 cell line. JOURNAL OF JIROFT UNIVERSITY OF MEDICAL SCIENCES, 8(1 ), 574-585. SID. https://sid.ir/paper/414904/en

    Vancouver: Copy

    Balouchi Adeleh, FAZILATI MOHAMMAD, HABIBOLLAHI SAEED, NAZEM HABIBOLLAH, Hejazi Seyed Mohammad Hossein. The effect of hydroalcoholic extract of Moringa oleifera leaves in a mouse model of colon cancer induced by CACO2 cell line. JOURNAL OF JIROFT UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2021;8(1 ):574-585. Available from: https://sid.ir/paper/414904/en

    IEEE: Copy

    Adeleh Balouchi, MOHAMMAD FAZILATI, SAEED HABIBOLLAHI, HABIBOLLAH NAZEM, and Seyed Mohammad Hossein Hejazi, “The effect of hydroalcoholic extract of Moringa oleifera leaves in a mouse model of colon cancer induced by CACO2 cell line,” JOURNAL OF JIROFT UNIVERSITY OF MEDICAL SCIENCES, vol. 8, no. 1 , pp. 574–585, 2021, [Online]. Available: https://sid.ir/paper/414904/en

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