Background: Pressure ulcers are among the most serious skin and tissue disorders and put a heavy financial burden on healthcare systems. These ulcers break through the body’ s first line of defense and can lead to severe consequences such as septicemia and death. Nowadays, most conventional treatments are very costly; therefore, the production of less expensive medications including herbal remedies is crucial. This study aimed to determine the healing effect of Dr Kamkar's herbal cream in one to third stage Pressure Ulcer. Methods: This single-blind randomized clinical trial was conducted on 65 patients aged 40-80 years with stage1-3 Pressure ulcers at Imam Ali Hospital in Karaj. The control group was treated with zinc oxide cream, while the intervention group was treated with Dr Kamkar ’ s herbal cream. Ulcers were measured according to the Pressure Ulcer Scale (PUSH) at the beginning of hospitalization and weekly for 8 weeks and the PUSH scores in the two groups were compered. Data analysis was carried out using SPSS version 23. Results: The results showed that in the intervention group the slop of decline in the PUSH score was greater in comparison to the control group. Regarding the area of the lesions, exudation and tissue regeneration, the levels of improvement in the intervention and control groups were 85% and 18%, respectively. Conclusion: According to our data, a significant difference in the mean scores of the pressure ulcer was observed between the two groups (P ≤ 0. 0001). It can be concluded that Dr Kamkar ' s healing cream is effective in the treatment of stage one to third pressure ulcers.