Aims: Extramarital affair is a threat to personal and family health. However, due to taboos, experts and researchers have not paid serious attention to this issue as an alarm for the health of the individual, family and society. The present study, with a qualitative approach, explains the perception and experience of married women involved in extramarital affairs, and finally, some verses and hadiths related to the findings of the study are given. Methods: This qualitative study has been done with the approach of contractual content analysis. Targeted sampling was performed through semi-structured interviews with maximum diversity on 15 married women with extramarital affair experience. Simultaneously with data collection, data analysis was continued by MAXQDA software version 10. As the interviews progressed, the main patterns and meanings within the interviews became clear and subcategories and categories were formed. Findings: The findings of this study showed that most of the women involved in extramarital affairs had a marital conflict with their spouses and entered into this relationship model to saturate their psychological emptiness. The death of values and emotional dichotomies and the destructive effect of these relationships on individual and family health were reflected in most of their statements. Finally, verses and hadiths related to the subcategories of the spouse mistreatment, emotional gaps, sexual incompatibility, feelings of shame and guilt and also the categories of secret friendships and adultery were mentioned. Results: Extramarital affairs are a threat to the health of the individual, the family and, consequently, society. Therefore, the need for life skills counseling and strengthening marital relationships is becoming more and more apparent. Also, informing the couples about the divine commands and Islamic teachings will definitely be effective in changing the attitude towards extramarital affairs.