Introduction It is important investigative association anthropometric indexes with cardiovascular risk factors for determining cardiovascular disease. Therefore, the aim of the present study was to evaluate the relationship between anthropometric indexes and cardiovascular risk factors in academic members of Islamic Azad University of Khomeinishahr. Methods and Materials A total of 158 (30 women and 128 men) faculty members aged between 30 to 65 years from university of Khomeinishahr were selected in a sampling based, cross-sectional survey. The Relationship between anthropometric indexes (Hight, Wight, Waist Circumference, Hip Circumference, WHR, WSR, BMI and BF% with cardiovascular risk factors (Tg, Tcho, HDL, and LDL) were determined. For data analysis, statistical significances were assessed by t test and Pearson Correlation. Results The results of this study showed that in females group there were significant relationships were observed between Tg with wight, WC, WHR and BMI indexes (P <0/05). While, no significant relationships were observed between Tcho, LDL and HDL with anthropometric indexes (P > 0/05). Furthermore, 26. 4% of variance in women's HDL can be explained by changes in their hip circumference. However, in males group there were positive significant correlations between Tcho and height, WHR, WHtR and BF% (P <0/05). But, no significant relationships were observed between LDL with anthropometric indexes (P > 0/05). Conclusion Results of this study indicate probably there is overweight and obesity in both genders. Therefore, evaluations and presentation of interventional programs in the lifestyle and raising awareness to control and prevent the problems associated with overweight and obesity are suggested.