Background and Aim: Increased plasma levels of HCY (homocysteine), CRP (C-reactive protein), TNFα (tumor necrosis factor), cTnI (cardiac troponin I) and cTnT (cardiac troponin T) are known as inflammatory risk factors for cardiomyopathy. So, this study aimed to investigate the effects of 8 weeks combined, interval aerobic and continuous aerobic training on HCY, CRP, TNFα , cTnI, cTnT, lipid profile and performance of military personnel aged 30-45 years old in cold and mountainous climate. Methods: 30 Military men aged 30-45 years were randomly assigned into three groups of 10 people, including as combined, interval aerobic and continuous aerobic training groups. Training protocol was implemented for 8-week, three sessions a week and each session takes about 90 minutes on a regular basis by 60% to 80% of 1RM (in complex training group) and VO2max (in aerobic training group) in cold (November/January-with a temperature difference of %5 lower than the average daily temperature) and mountainous climate of Tabriz city. Serum levels of cTnI, cTnT, Lipid Profile (LDL, HDL, and TGC), HCY, CRP, and TNF-α were assessed using ELISA and electrochemiluminescence methods. Results: 8 weeks of combined, interval aerobic and continuous aerobic training protocol, significantly decreased the serum levels of cTnI, cTnT, Lipid Profile (LDL, HDL, TGC), HCY, CRP and TNF-α in Military personnel (P<0. 05). Also, ANOVA and bonferroni post-hoc test revealed that the reduction of basic rates of these factors was relatively lower in the combined training group compared to interval aerobic and continuous aerobic training groups (P<0. 05). Conclusion: Implementation of 8 weeks of combined training decreased cardiovascular risk factors and catabolic responses, as these changes improve the performance of military personnel in organizational missions of cold and mountainous climate.