The aim of the present study was to evaluate the effect of memory specificity training on cognitive failure in patients with major depression. The method of study was the semi-experimental, pretest-posttest design with follow-up stage and the control group. Using available sampling method and targeted with research topic, 30 individuals (15 individuals the experimental group and 15 individuals the control group) after diagnosed their major depressive disorder and then clinical interviews, were selected as the sample. The instrument in this study were Beck Depression Inventory-Second Edition and cognitive failures questionnaire by Broadbent et al. The experimental group received 4 sessions, one hour and half, under the memory specificity training. After completing the training sessions, both the experimental and control groups were imposed to post-test and again one month later both groups were follow-up. Data were analyzed using analysis of variance with repeated measures. The results showed that memory specificity training had significant effects on cognitive impairment and distraction components (distractibility, memory problems, blunders, not reminder names), memory problems, inaccurate errors, and lack of reminder. These results were maintained at the follow-up stage. Considering the effect of memory specificity training on the reduction of cognitive deficits in patients and the continuation of their effects, it is necessary to use this training to prevent and treat patients with major depression.