JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES
Year:2019 | Volume:17 | Issue:11 |Papers Count:10

Background and Objectives: Due to the approved antioxidant effects of curcumin, this study was conducted to investigate the hepatoprotective effects of curcumin against methandienone (dianabol) induced hepatotoxicity in male mice. Materials and Methods: In this descriptive study, 35 adult male mice (weight=35± 2 g) were randomly assigned into five groups. The first group received 0. 2 ml of normal saline and second group received dianabol at 20 mg/kg/day orally. The treatment groups treated with 20 mg/kg/day of dianabol plus 50, 100 and 200 mg/kg/day of curcumin, during 8 weeks by gavage. At the end of the experiment, the level of alkaline phosphatase, alanine aminotransferase and aspartate amiotrasferase enzymes were measured and the quantitative changes of liver tissue were examined using stereological procedures. The data were analyzed using one-way ANOVA and Tukey’ s post-hoc test. Results: The volume of the liver, hepatocytes, sinusoids as well as alanine aminotrasferase and alkaline phosphatase levels increased significantly in dianabol treated group as compared with the control group (p<0. 05). Curcumin at 100 and 200 mg/kg doses significantly decreased the volume of the liver, hepatocytes, and sinusoides as well as the alanine aminotrasferase and alkaline phosphatase levels when compared to the dianabol treated group (p<0. 05). Conclusion: It seems that curcumin due to its anti-oxidant and anti-inflammatory properties can inhibit hepatic structural and functional alterations following dianabol administration.

Background and Objectives: Breastfeeding self-efficacy is a modifiable and effective factor in initiation and continuation of breastfeeding. So, modifying breastfeeding self-efficacy by identifying the affecting factors is one of the strategies to improve breastfeeding status. This study was conducted to determine the breastfeeding self-efficacy status and its affecting factors in Kosar Hospital of Qazvin in 2016-2017. Materials and Methods: This descriptive study consisted of 350 mothers who were admitted to the postpartum unit of the Kosar Hospital of Qazvin during the last 24 hours. The data were collected using demographicobstetric questionnaire and short form of breastfeeding self-efficacy scale and evaluated using the independent t-test, one-way ANOVA and multiple liner regression. Results: Mean and standard deviation of breastfeeding self-efficacy was 57. 28± 7. 65. Among the factors studied, pariety (p=0. 012), previous breastfeeding experience (p=0. 001), planned breastfeeding type (p=0. 008) and duration (p=0. 025) and mother's satisfaction from infant feeding in the hospital (p<0. 001) were significantly correlated with breastfeeding self-efficacy. Conclusion: Based on the results of this study, there are some factors that associate with breastfeeding selfefficacy and can predict it. We can modify the factors that affect breastfeeding self-efficacy by educating health personnel and conducting interventions in hospitals and health centers, and subsequently improve the breastfeeding status.

Background and Objectives: Diabetes mellitus is accompanied by oxidative stress and leads to reproductive disorders. With respect to antioxidants present in Thymus caramanicus, the effect of hydroalcoholic extract of it on testis weight, serum testosterone, lipid peroxidation and testis antioxidant enzymes levels were investigated in streptozotocin (STZ) induced diabetic male rats Materials and Methods: In this experimental study, in order to induce experimental diabetes model, a single dose (65 mg/kg, i. p) of STZ was intraperitoneally injected in rats. After 7 days, diabetic rats with fasting blood glucose level above 250 mg/dl were divided into 3 groups of 6 and received distilled water (1 mL), extract (500 mg/kg), glibenclamide (20 mg/kg) individually by gavage for 14 days. One group of normal animals were also used. At the end of treatments period, fasting rats were anaesthetized, and blood samples were collected for serum testosterone level measurement. Rats’ testes were also used for evalauation of catalase (CAT) and superoxide dismutase (SOD) antioxidant enzymes activities and malondialdehyde (MDA) level. Statistical analysis of data was performed using one-way ANOVA and Tukey’ s post-hoc test. Results: Administration of T. caramanicus extract in diabetic rats, significantly increased testis and body weight, serum levels of testosterone, catalase (p<0. 001) and superoxide dismutase enzymes activities (p<0. 047) in testis but significantly decreased MDA level (p<0. 004). Conclusion: Hydroalcoholic extract of T. caramanicus had beneficial effects on male reproductive system and exerted antilipid peroxidative and antioxidant properties in the testis of diabetic rats.

Background and Objectives: Musculoskeletal disorders is very common in drivers of public vehicles. Therefore, the purpose of this study was to measure the correlation between muscle fatigue assessment (MFA) and Cornell musculoskeletal discomfort questionnaire (CMDQ) in taxi drivers in Shahroud in 2017. Materials and Methods: This descriptive study was performed on 140 taxi drivers in Shahroud in 2017. Data were collected using demographic questionnaire, CMDQ and MFA chart. Statistical analysis was performed by descriptive statistics (frequency, percentage, mean) and inferential statistics (Eta coefficient). Results: The MFA results showed that 82% of lumbar muscle fatigue level was very high. The CMDQ results also showed that most musculoskeletal disorders was in the lower back and the least musculoskeletal disorders was in the forearm. Correlation between MFA and CMDQ showed that the highest correlation was in the back region with Eta=0. 574 and the lowest correlation was in the neck region with Eta=0. 294. Conclusion: The high correlation between MFA and CMDQ showed that MFA can be used instead of CMDQ. CMDQ is a self-report method and there is the possibility of non-cooperation or false report.

Background and Objectives: Chamomile has beneficial effects on ameliorating obesity, similar to the effects of exercise training. This study was designed to evaluate the effect of eight weeks aerobic interval-resistance training combined with chamomile consumption on body Composition and glucose homeostasis in overweight and obese women. Materials and Methods: In this randomised clinical trial study conducted in Khomam city in 2018, 29 overweight and obese women (overweight=11 and obese=18) were randomly selected and divided into three groups including training (65 min aerobic interval-resistance training, three times per week; n=9), training-Chamomile (65min concurrent training, three times per week; 1. 5 g Chamomile consumption, three times per day for eight weeks; n=10) and a control (no intervention; n=10) for 8 weeks. Body composition and glucose homeostasis variables were assessed at baseline and after the end of interventions. The results were analyzed using paired t-test and one-way analysis of variance. Results: Training-chamomile intervention was associated with markedly decreased amount of body mass index and body fat percent (p<0. 001). However, there was no significant difference in the concurrent training and control groups (p>0. 05). In addition, there were no significant changes in fasting blood sugar, insulin or homeostatic model assessment for insulin resistance (HOMA-IR) in any groups (p>0. 05). No significant difference in body composition and glucose homeostasis between the groups was detected at 8-weeks of intervention (p>0. 05). Conclusion: Considering the results, Chamomile consumption combined with aerobic-resistance training can probably be effective in improving body mass index and body fat percent in overweight and obese women.

Background and Objectives: Today, cardiovascular disease, in addition to death, causes disability in the affected population. Therefore, there is a need for a tool to assess the level of health and disability of these people. Assessment of the tool acceptability is a fundamental step in order to make necessary corrections if cultural, educational or inappropriate issues exist. The present study was designed to evaluate the acceptability level of participation and autonomy evaluation tool in Iranian patients with positive Angiography. Materials and Methods: This descriptive study was performed on 41 patients with positive angiography in the cardiovascular clinic of Rafsanjan in 2017. The IPA-P questionnaire was used to assess the acceptability of the instrument for measuring participation and autonomy in the patients, and the results were reported as descriptive statistics (mean, standard deviation, number and percentage). Results: On average, 84. 4% (35 people) of the patients confirmed the comprehensibility of the questions of the IPA-p questionnaire. Also, on average, 66% (27 people) of the patients reported the relationship between the different areas of the questionnaire and their health status "almost to many". Eight patients (19. 5%) suggested that a discussion of marital affairs be added to the questionnaire. Conclusion: The results showed that IPA-p questionnaire was an acceptable tool for measuring the participation and autonomy level in patients with positive angiography in Persian language.

ackground and Objectives: Much of the general health of nurses is achieved in establishing relationships with others. The purpose of this study was to determine the role of cognitive fusion and social intelligence in predicting general health of nurses in hospitals of Parsabad City, 2017. Materials and Methods: In this descriptive study, the research population included all nurses working in Parsabad city hospitals in 2017. A sample of 120 individuals was selected through simple random sampling and descriptive, general health, cognitive fusion and social intelligence information were collected. Data were analyzed by descriptive statistics, Pearson’ s correlation coefficient and multiple linear regression. Results: The results showed that cognitive fusion with beta-0. 21 (T= 2. 73), social intelligence with beta 0. 45 (T=6. 18) and age with beta-0. 41 (T=4. 33) can significantly predict public health. Conclusion: The findings indicated that cognitive fusion and social intelligence are important factors in the overall health of nurses.

Background and Objectives: Since noise pollution as an important environmental problem, affects people’ s health, the present study aimed at evaluating noise pollution level and the pattern of its changes in the area. Materials and Methods: In the present cross-sectional study, the equilibrium sound levels (Leq) were measured in 16 stations, during fall-winter of 2016 and spring-summer of 2017, in the morning and evening peak traffic times at all weekdays using the KIMO-DB100 Sound Level Meter. The data were analyzed using the Geostatistical Analyst tool and based on Inverse Distance Weighting (IDW) interpolation method. Results: The results showed that the highest and lowest Leq were related to working days and Friday, respectively. The equivalent sound level in winter is as a minimum 1 dB higher and in summer as a minimum 1. 5 dB lower than the other seasons. The minimum equivalent sound level was 56. 1 dB throughout the sampling period and the maximum was 86. 75 dB. The extents of equivalent sound in all stations were more than standard limit of residual areas (55 dB). Conclusion: According to the results, noise pollution is spread almost in all areas and hours of Zone 1-Region 6 of Tehran. This issue illustrates the necessity of applying noise pollution control technologies in this region.