The Effect of Hydroalcoholic Extract of Thymus caramanicus on Serum Testosterone and Testis Antioxidant Enzymes Levels in Streptozotocin Induced Diabetic Rats: An Experimental Study

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HONARI N.; POURABOLI I.

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Journal: Journal of Rafsanjan University of Medical Sciences Year:2019 | Volume:17 | Issue:11 Page(s): 1017-1030

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Title

The Effect of Hydroalcoholic Extract of Thymus caramanicus on Serum Testosterone and Testis Antioxidant Enzymes Levels in Streptozotocin Induced Diabetic Rats: An Experimental Study

Author(s)

HONARI N. | POURABOLI I. | Issue Writer Certificate

Keywords

Thymus caramanicusQ1

Diabetes mellitusQ2

AntioxidantQ2

RatQ2

TestisQ2

Abstract

Background and Objectives: Diabetes mellitus is accompanied by oxidative stress and leads to reproductive disorders. With respect to Antioxidants present in Thymus caramanicus, the effect of hydroalcoholic extract of it on Testis weight, serum testosterone, lipid peroxidation and Testis Antioxidant enzymes levels were investigated in streptozotocin (STZ) induced diabetic male Rats Materials and Methods: In this experimental study, in order to induce experimental diabetes model, a single dose (65 mg/kg, i. p) of STZ was intraperitoneally injected in Rats. After 7 days, diabetic Rats with fasting blood glucose level above 250 mg/dl were divided into 3 groups of 6 and received distilled water (1 mL), extract (500 mg/kg), glibenclamide (20 mg/kg) individually by gavage for 14 days. One group of normal animals were also used. At the end of treatments period, fasting Rats were anaesthetized, and blood samples were collected for serum testosterone level measurement. Rats’ testes were also used for evalauation of catalase (CAT) and superoxide dismutase (SOD) Antioxidant enzymes activities and malondialdehyde (MDA) level. Statistical analysis of data was performed using one-way ANOVA and Tukey’ s post-hoc test. Results: AdministRation of T. caramanicus extract in diabetic Rats, significantly increased Testis and body weight, serum levels of testosterone, catalase (p<0. 001) and superoxide dismutase enzymes activities (p<0. 047) in Testis but significantly decreased MDA level (p<0. 004). Conclusion: Hydroalcoholic extract of T. caramanicus had beneficial effects on male reproductive system and exerted antilipid peroxidative and Antioxidant properties in the Testis of diabetic Rats.

Cites

IN VITRO EVALUATION OF ANTIOXIDANT CAPACITY OF THYMUS KOTSCHYANUS HYDRO-ALCOHOLIC EXTRACTS AND ITS EFFECT ON SERUM PARAOXONASE 1 ACTIVITY IN DIABETIC AND HEALTHY PERSONS

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APA: Copy

HONARI, N., & POURABOLI, I.. (2019). The Effect of Hydroalcoholic Extract of Thymus caramanicus on Serum Testosterone and Testis Antioxidant Enzymes Levels in Streptozotocin Induced Diabetic Rats: An Experimental Study. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, 17(11 ), 1017-1030. SID. https://sid.ir/paper/71153/en

Vancouver: Copy

HONARI N., POURABOLI I.. The Effect of Hydroalcoholic Extract of Thymus caramanicus on Serum Testosterone and Testis Antioxidant Enzymes Levels in Streptozotocin Induced Diabetic Rats: An Experimental Study. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES[Internet]. 2019;17(11 ):1017-1030. Available from: https://sid.ir/paper/71153/en

IEEE: Copy

N. HONARI, and I. POURABOLI, “The Effect of Hydroalcoholic Extract of Thymus caramanicus on Serum Testosterone and Testis Antioxidant Enzymes Levels in Streptozotocin Induced Diabetic Rats: An Experimental Study,” JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, vol. 17, no. 11 , pp. 1017–1030, 2019, [Online]. Available: https://sid.ir/paper/71153/en

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