Journal of Sabzevar University of Medical Sciences
Year:2019 | Volume:26 | Issue:3 |Papers Count:17

Background Herbicides, including atrazine, are among the most important newly discovered contaminants found in water bodies and are hazardous to human health and the environment. adsorption is one of the best techniques used to remove these contaminants from contaminated water. Materials and method In this study, two carbon from waste Pomegranate and calligonum Comosum were used to remove atrazine herbicide. After chemical activation these carbons with NH4Cl, and then 800 ° C for 2 hours, parametric tests were performed and the effect of pH, adsorbent concentration, atrazine concentration and contact time were investigated; then absorption equilibrium tests; absorption capacity and its isotherms investigated for the removal of atrazine by two carbons were calculated. Results The results showed that the carbon produced from the calligonum Comosum wood in optimal conditions at pH =7; carbon concentration 0. 2 g/L, and the mixing time of 50 minutes could remove 100% atrazine at 25 mg/L. The carbon produced from pomegranate in optimal conditions pH =6; carbon concentration of 0. 2 g/L and mixing time of 50 minutes could remove 91. 5% atrazine to 25 mg/ L. Absorption equilibrium tests showed that the absorption capacity of carbon Calligonum Comosum and pomegranate were 672 and 645mg/g respectively. Discussion The results of this study showed that both carbons have high absorption capacity in the removal of atrazine herbicide and can be an effective and economical absorbent for the removal of this contaminant from natural waters.

Introduction Breast cancer is the most common tumor malignancy among women worldwide. Studies have revealed new class of RNA molecules named Long non-coding RNAs that play important role in tumor development, progression and metastasis. Therefore, this study aimed to evaluate long non-coding RNA lncUSMycN expression in breast cancer. Methods In this study, 40 breast tumor with invasive ductal carcinoma and 40 normal marginal tissues were collected and after RNA extraction using TRizol kit, cDNA was synthesized. Expression level of lncUSMycN was obtained by applying qRT-PCR method. In order to evaluate association of lncUSMycN expression in tumor compared to normal tissues REST software was used. Biomarker potential of lncUSMycN was evaluated by drawing ROC curve using SigmaPlot. In addition, relationship between lncUSMycN expression and clinicopathological features was analysed. Results Results from REST indicated significant upregulation of lncUSMycN in tumor tissues compared to normal marginal specimens (95% CI, p =0. 001). ROC curve analysis demonstrated the biomarker potential of lncUSMycN (ROCAUC =0. 72, p=0. 0006). Evaluation of the relationship between lncUSMycN expression and clinicopathological features revealed that there are significant association between lncUSMycN expression and early stages (95% CI, P=0. 005) and well-differentiated tumors (95% CI, P=0. 046). Conclusion Considering upregulation of lncUSMycN expression in invasive ductal carcinoma this lncRNA may be probably considered as a new potential diagnostic biomarker for breast cancer.

Background Emergence of drug resistant strains and the limited use of antifungal drug due to possible toxic effects on humans, the high cost of their production and environmental pollution has made the search for novel bio-antifungal compounds a necessity. Microorganisms, particularly soil bacteria produce a wide range of active antimicrobial substances that some of them have antifungal properties. The purpose of this study is isolation and identification of the bacteria affecting the growth of fungi from Khorramabad agricultural soil. Materials and Methods Agricultural soils were collected from different areas of Khorramabad, Lorestan Province. The bacteria were isolated using nutrient broth and nutrient agar, then, the antifungal activity of their extracts and supernatant in the SCA media on several species of fungi was studied applying disk diffusion method. Results Four strains showing a remarkable antifungal effect against some fungi, including Aspergillus niger, Aspergillus flavus, Aspergillus fumigatus and Candida albicans. These isolates were identified by biochemical features and 16S rRNA sequence. Analysis of their sequencing through BLAST in NCBI data bank showed that these bacterial similarly closed to Pseudomonas sp. and Acinetobacter sp. genus. Conclusion This study was the first report of antifungal analysis of soil isolated bacteria from Khorramabad. These bacteria could be a potential candidate for biocontrolling pathogenic fungi. The extraction, identification and development of their inhibitory metabolites can be used in the design and production of antifungal agents.

Background soil pollution to heavy metals is elevating that is dangerous for human health. According to this, mining activities to extract different heavy metals such as Pb and Cd can increase soil pollution. Thus, this research was done to evaluate Health risk assessment of heavy metals (Cd and Pb) in greenhouse products harvested from greenhouses around Irankooh mine. Materials and Methods In this study 10 cucumber, tomato and bell pepper greenhouses were selected randomly around Irankooh mine. At the time of harvest, fruit and soil sampling were done. In each sampling, 10 fruit samples of each products and soil surface from different parts of greenhouses were randomly selected for analysis. Results The highest and lowest daily intakes of Cd and Pb in the group age of 3-6 were determined with daily consumption of 55 and 100 g bell pepper and cucumber, respectively. The same results were observed for adult people in the age 18-35. The hazard quotient of Cd for all age groups was greater than the Pb hazard quotient. The highest hazard quotient of both Cd and Pb were due to the dermal contact with polluted soil and the lowest of them results from oral way. Conclusions The results of this research were shown that high Pb and Cd concentration in the greenhouse vegetable which produced around Irankkoh is an important concern for consumers health of these vegetables that should be more considered.

Aims Hemodialysis patients experience in during the hemodialysis levels of nausea it’ s affected on adequacy dialysis. This study performed with the aim assessing the effect of muscle relaxation on nausea and dialysis adequacy in hemodialysis patients. Methods This two grouped experimental controlled trial was conducted on 90 hemodialysis patients as the control case group from Gonabad and zahedan hospitals in 2015. For whom Benson muscle relaxation performed in their home after the initial training by the researcher, for 15-20 minutes, twice a day during one month. Nausea and dialysis adequacy evaluated before and after the intervention in both groups. The collected data were analyzed using independent t-test, chi-square and Mann-Whitney U tests through SPSS software version 21. The p-value was considered significant at 0. 05 levels. Results The mean scores of nausea and adequacy dialysis in case group, before the intervention, were 0. 22± 1. 04 and 1. 35± 0. 39 which nausea received to 0. 02± 0. 15 and adequacy dialysis1. 50± 0. 43 after the intervention. Wilcoxon test showed This difference was not significant in nausea (p=0. 65), but result t paired showed it was significant in adequacy dialysis (p=0. 003). Conclusion Muscle Benson relaxation can be considered as a cost effective, simple and secure way to increase adequacy dialysis in the hemodialysis patients.

Today, molecular typing methods play an essential role in many medical issues. These techniques, which are introduced every day by introducing new methods, increase the accuracy of their results. They have also enabled us to better understanding the status quo, advice on health system problematic subjects, and avoid further preventive measures from occurring. Molecular typing methods allow researchers to study the association between isolated pathogens and compare the results to their colonized origin. It also helps to differentiate and detect environmental contaminations from infectious species, identify and track hospital infections from its source. Nowadays, these methods have been used in many countries in health centers and hospitals. These tests have been able to play a significant role in controlling the spread of infection and reducing health costs. One of these tests is Pulse Field Jel Electrophoresis (PFGE) that plays an important role in water-and food-borne disease. Set of the whole system requires huge investment throughout the country need in order to provide a laboratory network to register all sporadic and epidemic cases. This program will not be progress without the support of health system with cooperation of and research centers. Therefore, in this paper, we tried to examine the features and limitations of the pulse field electrophoresis, and provide a functional model that would help the health system to provide the required warning. It is hoped that with the corrective comments of the dear scholars, there would be an appropriate system for achieving this goal.

Background and objective Town Board Stations (TBS) installations with increment in gas consumption and overloading are one of the sources of noise pollution. The present study was aimed to assess and provide an occupational noise exposure control plan in TBS. Methods Area noise measurement and frequency analysis was performed according to ISO 9612(2009). After the determination of the range of sound pressure level, predominant source of noise was identified. In addition, dosimetry was conducted to determine the personal exposure during a work shift. In the next step, acoustical analysis of TBS of the sample, construction was conducted based on acoustical absorbance properties. Installation of absorbent materials was recommended and the efficiency of the interventions was assessed. Results sound pressure level was in the range of 68. 64 to 95. 30 dB(A) in TBS. The minimum and maximum effective sound absorption of internal surfaces were 3. 61 and 27. 64 Sabine m2, respectively. The average noise exposure dose for maintenance workers was 121%. After installation of absorbent materials on ceiling and walls, the effective sound absorption of the surfaces was improved to a maximum of 210. 35 Sabine m2 and a minimum of 40. 35 Sabine m2. The noise reduction prediction for these control plan will be 8. 69-11. 6 dB(A). Conclusions The main reason of noise in the TBS was the passage and turbulence of gas flow in the mechanical unit, and reflective surfaces in constructions enclosing the installations. The control strategy, including the use of absorbent materials on ceiling and walls, was determined to reduce the sound pressure level to occupational exposure limit.

Introduction and Aims Some of people prefer daily activities; others, nightly ones. Studies have shown that performance levels may be affected by circadian rhythms. The high mental workload occurs when the task is greater than the capacity of the operator. Regarding the probable relationship between circadian types and mental workload, we decided to evaluate this factor in the assembly workers of a manufacturing company. Materials and Methods The study was a descriptive-analytic and cross-sectional one being carried out among 120 female assembly workers of manufacturing company. In order to evaluate of circadian types and mental work load, Iranian version of MEQ (Moring-Evening Questionnaire) and NASA-TLX (NASA-Task Load Index) have respectively been used. Data analysis was carried out by using SPSS 20. It is noteworthy to mention that P value

Background and Aims one of the hormones that appears to play an important role in regulating body growth is ghrelin. This study aimed to determine the association between Maternal serum ghrelin level and neonatal anthropometric indicators at birth. Materials & Methods In this cohort study, 35 eligible pregnant women in their first trimester that were allocated by Using Convenience sampling were divided and matched in terms of BMI before pregnancy into normal and higher than normal BMI groups A ( n=14) and B ( n=21). Serum ghrelin level was measured during 6-12 and 15-20 weeks of gestation using ELISA method. Results Mean non-fasting serum gherlin level (first and second trimesters) had not significant deference between two groups (p1=0. 93, p2=0. 76, in first and second trimester, respectively). Also there is a ascending increase in mean serum ghrelin level with increasing gestational age from the first to the second trimesters in both groups but was not significant (pa=0. 15, pb=0. 24, in A and B group, respectively). No significant correlations were detected between non-fasting serum gherlin level (first and second trimesters) and neonatal anthropometric indicators. Conclusion The lack of any direct relationship between Maternal serum ghrelin level and neonatal anthropometric indicators does not support the hypothesis that ghrelin has major role in foetal growth

Background Pain interference is one of the important characteristics of chronic pain that determines the type and route of treatment. However, limited information is available about interventions efficacy on pain interference. Therefore, the aim of this study was to evaluate the effect of Mindfulness-based Cognitive Therapy (MBCT) on activity and emotional pain interference in patients with primary headache. Methods A clinical trial was conducted in 2017 and 2018 Imam Hossein hospital in the city of Tehran, Iran. Then, using the sampling judgment among 94 in patients with chronic headache, 85 were selected and randomly assigned into two groups: MBCT (43 patients) and control group (42) and were evaluated in two stages. The Numeric pain rating scale (NRS) Brief Pain Inventory (BPI), were measured. All data were analyzed by multivariate analysis of covariance. The results were reported using intent-to-treat (ITT) analyses and completer samples. Findings In ITT analyses statistically significant were found for emotional pain interference

Background Self-efficacy is one of the personal resources that plays an important role in social assessment and coping resources. Therefore, the present study was conducted to investigate the relationship between emotional inhibition and fear of social evaluation with self-efficacy in men and women. Materials and Methods The research method was descriptive-correlational. The study population included all women and men in the 6th district of Tehran in 2017. Via convenient sampling method two-hundred people (100 women and 100 men) were selected. To collect the data, Roger & Nesshoever, emotion control Questionnaire, Brief Fear of Negative Evaluation Scale (FNES-B), and General Self-Effi cacy Scale (GSE-17) were used. The data were analyzed by Pearson correlation coefficient, independent t-test by SPSS-20. Results The results showed that there is no significant relationship between emotional inhibition and self-efficacy in two gender. Also, there is a negative and significant relationship between the fear of negative evaluation of others and self-efficacy in men (-0. 54), women (-0. 43) and total (-49. 4). The results of t-test indicated that there was no significant difference between the two sexes in the variables of emotional inhibition and fear of evaluation of others and the difference in self-efficacy in men and women. Conclusion Based on the results, one of the variables that affect the self-efficacy of fear is the negative evaluation of others and the amount of self-efficacy varies according to gender and is higher in men than in women due to educational and cultural factors.

Background Pregnancy is associated with many physiological and biomechanical changes that leading to common complaints. teaching to mother can empower her to minimize these complaints. the aim of this study was to compare the effectiveness of not in perosn education, with face-to-face training on reducing to prevalence of pregnancy complications. Methods This is a pre-and post-semifinal study. In 2017, 100 pregnant women under the control of randomly selected 3 health centers in Mashhad were selected. After doing a pretest and, intervention was conducted using SMS, telegram and in-person training. One and two months after the intervention, a post-test questionnaire was completed. Data were analyzed using SPSS20 and Friedman, Kruskal-Wallis, Chi-square and Anova statistical tests. Findings The "common complaints rate of pregnancy", one-two week months after the intervention, before and after intervention in all three teaching methods, using telegram (p

Background Ischemic heart disease is the first cause of early death in the world. One of the main treatments for patients with acute coronary syndrome is the use of anticoagulants. The aim of this study, The aim of this study was to compare effect of two methods of intermittent intravenous injection and continuous infusion on APTT in patients with ACS. Materials and Methods clinical trial was performed on 60 patients selected by random sampling in Neishabour Hospital in 2018. To data gathering were used the demographic information questionnaire, and APTT checklist. The intravenous injection group received 2500 units heparin every 3 hours and infusion group was given 1000 units per hour and APTT was controlled. Data analysis was done using SPSS-16 software and sinifiant level was considered to be less than 0. 05. Results Mean APTT level in first stage was 40. 8 ± 11. 17 and 38. 87 ± 8. 86 in intermittent intravenous injection and continuous infusion groups respectively. In the 8th stage, mean APTT level in intravenous injection group was 55. 03 ± 8. 41 and in continuous infusion group was 55. 7 ± 14. 09. Independent t-test did not show a significant difference between the two groups (P> 0. 05). Conclusion Regarding to approximation of the results in two methods, alternate injection method can be used instead of continuous intravenous infusion. This method creates less constraints for the patient and reduces the burden on nurses due to don’ t need setting pump syringe, serum heparin preparation, and alleviation of alarms.

Background This study investigated the effect of 3-weeks Taper in hypoxic environment on the ratio of Bax / Bcl2 and alveolar epithelial cells populations in the lung. Materials and Methods Thirty-five rats (4 weeks old, weighing 8 ± 72 g) were divided in five groups: control (6 weeks), training (6 weeks), hypoxia (3 weeks), hypoxia-taper (3 weeks) and control (9 weeks). Samples entered to the hypoxia after six weeks of interval training and lived there for 3 weeks. another group with exposure to hypoxic environment, implementation Taper technique. Bax/Bcl2 ratio of lung measured by immunohistochemistry and type II and type I pneumocytes population of pulmonary alveolar measured with stereologically. Results Bax/Bcl2 ratio and type II pneumocytes population Increased and type I pneumocytes population Decreased After six weeks high intensity interval training (P≤ 0. 5). Bax/Bcl2 ratio and type I pneumocytes population of hypoxia group decreased compared with training group (P≤ 0. 5). three weeks taper in hypoxia group, Led to decrease of Bax/Bcl2 ratio, type II population pneumocytes and Increase of type I pneumocytes (P≤ 0. 5). Conclusion It seems high intensity interval training and subsequent hypoxia can increase pulmonary alveolar apoptosis. also appears taper is a Efficient Method to decrease of apoptosis lung.