The effect of three weeks taper in hypoxic environment on apoptotic index of Bax / Bcl2 and population of alveolar epithelial cells

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YADEGARI MEHDI; RIAHY SIMIN; MIRDAR SHADMEHR; HAMIDIAN GHOLAMREZA

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Journal: Journal of Sabzevar University of Medical Sciences Year:2019 | Volume:26 | Issue:3 Page(s): 393-402

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Title

The effect of three weeks taper in hypoxic environment on apoptotic index of Bax / Bcl2 and population of alveolar epithelial cells

Author(s)

YADEGARI MEHDI | RIAHY SIMIN | MIRDAR SHADMEHR | HAMIDIAN GHOLAMREZA | Issue Writer Certificate

Keywords

High intensity interval trainingQ1

pneumocytesQ1

hypoxiaQ1

taperQ1

apoptosisQ1

Abstract

Background This study investigated the effect of 3-weeks taper in hypoxic environment on the ratio of Bax / Bcl2 and alveolar epithelial cells populations in the lung. Materials and Methods Thirty-five rats (4 weeks old, weighing 8 ± 72 g) were divided in five groups: control (6 weeks), training (6 weeks), hypoxia (3 weeks), hypoxia-taper (3 weeks) and control (9 weeks). Samples entered to the hypoxia after six weeks of interval training and lived there for 3 weeks. another group with exposure to hypoxic environment, implementation taper technique. Bax/Bcl2 ratio of lung measured by immunohistochemistry and type II and type I pneumocytes population of pulmonary alveolar measured with stereologically. Results Bax/Bcl2 ratio and type II pneumocytes population Increased and type I pneumocytes population Decreased After six weeks High intensity interval training (P≤ 0. 5). Bax/Bcl2 ratio and type I pneumocytes population of hypoxia group decreased compared with training group (P≤ 0. 5). three weeks taper in hypoxia group, Led to decrease of Bax/Bcl2 ratio, type II population pneumocytes and Increase of type I pneumocytes (P≤ 0. 5). Conclusion It seems High intensity interval training and subsequent hypoxia can increase pulmonary alveolar apoptosis. also appears taper is a Efficient Method to decrease of apoptosis lung.

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APA: Copy

YADEGARI, MEHDI, RIAHY, SIMIN, MIRDAR, SHADMEHR, & HAMIDIAN, GHOLAMREZA. (2019). The effect of three weeks taper in hypoxic environment on apoptotic index of Bax / Bcl2 and population of alveolar epithelial cells. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, 26(3 ), 393-402. SID. https://sid.ir/paper/372846/en

Vancouver: Copy

YADEGARI MEHDI, RIAHY SIMIN, MIRDAR SHADMEHR, HAMIDIAN GHOLAMREZA. The effect of three weeks taper in hypoxic environment on apoptotic index of Bax / Bcl2 and population of alveolar epithelial cells. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;26(3 ):393-402. Available from: https://sid.ir/paper/372846/en

IEEE: Copy

MEHDI YADEGARI, SIMIN RIAHY, SHADMEHR MIRDAR, and GHOLAMREZA HAMIDIAN, “The effect of three weeks taper in hypoxic environment on apoptotic index of Bax / Bcl2 and population of alveolar epithelial cells,” JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, vol. 26, no. 3 , pp. 393–402, 2019, [Online]. Available: https://sid.ir/paper/372846/en

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