In these study moisture sorption isotherms curves for pistachio powder were obtained in 15, 25, 35 and 40°C, respectively. The curves related to pistachio kernel and whole pistachio was obtained in 15 and 35°C as well.Hysteresis phenomenon was observed in water activity range of aw: 0.2 to 0.7. The level of hysteresis decreased in whole pistachio, pistachio kernel, and pistachio powder respectively. Some mathematical models were studied for fitting of pistachio equilibrium moisture content (EMC) including BET, GAB, Smith, Sowing, Halsey and Henderson. Among these models, Smith model was found to fit the most properly on the experimental results. Thermodynamic relationship of Clausius -Clapeyron was used to determine the isosteric heat for adsorption and desorption of pistachio moisture. The results were sketched upon moisture content on dry basis.The results of this study will be used to optimize the drying process, storage conditions and packaging of pistachio nuts.