Background: The study of functional outcomes following orthopedic procedures, such as joint replacement, has become common in the last decade. To report only on radiographic changes, joint motion range or limb alignment after a knee arthroplasty, without evaluation of changes the patients feel in their general well-being or daily personal or social functions would be futile. The instruments for assessment are usually based on patients’ general health, or on possible post-operative improvement of certain daily functions. The functional outcome assessment instruments for knee replacement have not been validated in Iran. We are trying to show the validity of such instruments in knee arthroplasty performed in a university set-up in Iran. Methods: Sixty patients, 56 women and 4 men, who had undergone total knee arthroplasty by a single surgeon, were recruited for clinical evaluation and for filling out the questionnaires on 3 outcome instrument systems, namely SF-36, WOMAC and MACTAR. Two control groups consisting of 44 cases of similar age from general population with knee discomfort and susceptible to osteoarthritis as well as 26 patients scheduled for knee arihroplasty filled out the same questionnaires.Results: The health status measurement (SF-36), disease-specific outcome measure and patient preference arthritis scores all showed significant improvement in operated cases, in both short and long term follow-up groups. Certain aspects of function like socialization with others, attending religious ceremonies and similar activities, often requiring full knee bending and/or sitting on the carpeted floor, were the main reasons for dissatisfaction with the procedure. Conclusion: The knee arthroplasty increased quality of life, improved function and produced great satisfaction in the majority of cases in our society. This is, however, a viable option for people who could change their lifestyle and household and are able to make the adjustments mentally and financially.