Khoshk River which flows through Shiraz and pours into Maharloo Lake is a seasonal river. Different types of wastewater (domestic, business, industrial, and agricultural wastewater) run into this river.To examine the quality of the river>s water and the pollution caused by heavy metals (Cadmium, Zinc, Copper, Iron and Nickel), six stations were established and samples were taken from the water in 2005. Also, in the spring of 2005, some samples were taken from the products of the nearby farms and the rate of heavy metals found in them was measured. The average concentration of heavy metals in the rivers water was compared with the maximum allowable figures for drinking water, surface waters, irrigation, and aquatic creatures, using a t-student test (with a confidence level of 95%).The results showed that the water in station one (Moali Abad bridge) lacks heavy metals and is completely safe for any use. However, the water in the stations two (Namazi bridge), three (Parking bridge), four (Salman bridge), and five (Sharif Abad bridge) is not suitable for drinking, irrigation, and aquatic creatures, but it is safe as surface water. The water in station six (end of Kharchool) is not suitable for drinking and aquatic creatures, but it can be used for irrigation and is also safe as surface water.Regarding the farming products, it can be said that some of them contain heavy metals but only the rate of copper in all the plants and iron in only one case was more than the maximum allowable figures.