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Information Journal Paper

Title

The Effect of Intraperitoneal Injection of Carvacrol Administration on Lipopolysaccharides-Induced Renal Oxidative Stress in Male Rats

Pages

  133-146

Abstract

 Carvacrol is a natural monoterpene phenol which retains significant antibacterial, antifungal, anti-cancer and anti-inflammatory activity. However, the effect of Carvacrol on Oxidative Stress in Lipopolysaccharide-induced Acute Kidney Injury has not yet been reported. The present study aimed to investigate the protective effects of Carvacrol on Lipopolysaccharides-induced renal Oxidative Stress and inflammatory responses in male rats. Male Wistar rats (weighing 200 to 250 g, n=7 each group) were divided into the following groups: 1) control, 2) LPS, 3) LPS+Carvacrol 25 mg/kg, 4) LPS+Carvacrol 50 mg/kg and 5) LPS+Carvacrol 100 mg/kg. For inducing Acute Kidney Injury, 1 mg/kg LPS was injected intraperitoneally for 2 weeks. Carvacrol was administered intraperitoneally 30 minutes prior LPS injection. After preparation of renal homogenates, levels of inflammatory cytokines IL-1β and Oxidative Stress indexes (malondialdehyde, total thiol, catalase and Superoxide dismutase activity) were detected by ELISA and spectrophotometric methods, respectively. Our results showed that LPS injection increased malondialdehyde and IL-1β while, it reduced total thiol, catalase and SOD activity in the renal tissue. But, pretreatment with Carvacrol not only decreased malondialdehyde and IL-1β levels but also increased total thiol, catalase and SOD activity. Simple regression analysis revealed that MDA was positively correlated with IL-1β level). However, there was a significant negative correlation between MDA level and total thiol, SOD and CAT activities. Our results showed that Carvacrol protects the kidney by reducing IL-1β and preventing Oxidative Stress in the renal tissue. enal tissue.

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