Substituted Tetrahydrocarbazole Based on Indomethacin and Diclofenac with Heterocyclic Compound, Synthesis, Spectral and Antimicrobial Studies

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Mahdi Mustafa H.; Dawood Ashour H.; Shaheed Dhurgham Q.

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Journal Paper

Paper Information

Journal: Journal of Medicinal and Chemical Sciences Year:621 | Volume: | Issue: Page(s): 933-942

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Information Journal Paper

Title

Substituted Tetrahydrocarbazole Based on Indomethacin and Diclofenac with Heterocyclic Compound, Synthesis, Spectral and Antimicrobial Studies

Author(s)

Mahdi Mustafa H. | Dawood Ashour H. | Shaheed Dhurgham Q. | Issue Writer Certificate

Keywords

TetrahydrocarbazoleQ4

indomethacinQ4

DiclofenacQ4

CyclohexanoneQ4

Abstract

New 6-chloro-1,2,3,4-Tetrahydrocarbazole compounds were prepared from the reaction of Cyclohexanone with 4-chlorophenylhydrazine. The synthesis of heterocyclic compounds was carried out through the reaction of Cyclohexanone with 4-chlorophenylhydrazine, then the produced compound was treated with two NSAIDs (indomethacin, Diclofenac) by amide bond formation to form N-substituted THCZ by NSAIDs. The characterization of prepared compounds was identified using the 1H, 13C NMR and FT-IR spectroscopies. The antimicrobial activity of the synthesized compounds was tested in vitro to discover a good activity as antifungal and moderate as antibacterial, which was confirmed by the docking study of the compounds.

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