Evaluation of Biological Activity of 5-Fluoro-Isatin Thiosemicarbazone Derivatives

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Ganim Ramadan Mohamed Abdulhamid; Baloglu Mehmet Cengiz; Celik Altunoglu Yasemin; Kandemirli Fatma; Burhan Hakan; Aygun Aysenur; Sayiner Hakan Sezgin; Ozyigit Filiz; Sen Fatih

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF NANOSTRUCTURES Year:2020 | Volume:10 | Issue:3 Page(s): 509-517

Download Full-Text

View:

Download:

Cites:

Information Journal Paper

Title

Evaluation of Biological Activity of 5-Fluoro-Isatin Thiosemicarbazone Derivatives

Author(s)

Keywords

5-Fluoro-Isatin

Antimicrobial activity

DNA protection

Thiosemicarbazone

Abstract

Isatin based materials can exhibit a wide range of biological activities including antimicrobial, antiviral, antifungal, anthelmintic, antitumor, anti-HIV, anti-inflammatory, antidepressant, antioxidant, anticonvulsant, antitubercular, analgesic, and central nervous system depressant activities. In this study, four compounds containing 5-Fluoro-isatin thiosemicarbazone with methoxyphenyl or methoxyphenyl in different positions and zinc complexes were evaluated based on their biological activities. Compound 2 was the strongest compound affecting gram-negative bacteria compared to the other compounds. Also, this compound indicated better antimicrobial activity than positive control antibiotics. Besides, compound 3 was the only compound that inhibited the growth of Salmonella spp. such as Salmonella enteritidis ATCC 13076 and Salmonella typhimurium NRRLE 4463. 5-Fluoro-Isatin thiosemicarbazone and its derivatives also showed DNA protection property from moderate to good protections. Among them, compound 4 displayed the highest DNA binding affinity. These compounds possessed a capacity for utilization as drugs or drug additives based on their effects on bacteria strains and DNA binding affinity.

Multimedia

No record.

Cites

No record.

References

No record.

Cite

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans