Graphene Oxide as a Nanocarrier for Controlled Delivery of Indole

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Sadeghipour Yasin; Hafez Ghoran Salar; Shafiee Mostafa; Mousavi Seyed AmirHossein; Dehghani Fatemeh Sadat; Amani Ali Mohammad

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Scientific Information Database

ISSN: 2588-4824

Journal Paper

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Journal: JOURNAL OF NANOSTRUCTURES Year:621 | Volume: | Issue: Page(s): 534-542

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Title

Graphene Oxide as a Nanocarrier for Controlled Delivery of Indole

Author(s)

Keywords

BioavailabilityQ4

Drug DeliveryQ4

graphene oxideQ4

NanocarrierQ4

pH sensitiveQ4

Abstract

Regarding the specific physiochemical and biomedical properties of graphene oxide (GO), it has been a long time that experts have preferred anticancer drug cocktails to single drugs. Given that the former may develop a more balanced molecular basis for recent chemotherapeutic strategies. In this study, graphene oxide was investigated as a bioavailable Nanocarrier for indoles. The synthesized components were characterized using Fourier transform infrared (FTIR), X-ray diffraction (XRD), UV–Vis spectroscopies, and scanning electron microscopy (FE-SEM) techniques. Interestingly, maximum drug loading efficiency was achieved in the neutral media (pH=7). The release analysis in different media revealed higher rate in both acidic and basic media than in neutral media. However, the total loaded drug was released in less than 80 minutes in all the systems prepared. The MTT assay results toward mesenchymal stem cells exhibited a desirable biocompatibility of GO-indole and GO. Taken together, the prepared GO-indole has suitable drug loading efficiency.

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