TOXIC EFFECTS OF HYDROALCOHOLIC EXTRACT OF KIWI (ACTINIDIA CHINENSIS) ON HISTOLOGICAL STRUCTURE OF THE MALE SPRAGUE-DAWLEY RAT REPRODUCTIVE TISSUES

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DEHGHANI FARZANEH; TALAEI KHOUZANI T.; PANJEH SHAHIN M.R.; PANAHI Z.

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Journal: IRANIAN JOURNAL OF SCIENCE AND TECHNOLOGY TRANSACTION A- SCIENCE Year:2006 | Volume:30 | Issue:A1 Page(s): 19-25

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Title

TOXIC EFFECTS OF HYDROALCOHOLIC EXTRACT OF KIWI (ACTINIDIA CHINENSIS) ON HISTOLOGICAL STRUCTURE OF THE MALE SPRAGUE-DAWLEY RAT REPRODUCTIVE TISSUES

Author(s)

DEHGHANI FARZANEH | TALAEI KHOUZANI T. | PANJEH SHAHIN M.R. | PANAHI Z. | Issue Writer Certificate

Keywords

ACTINIDIA CHINENSISQ3

TESTISQ3

REPRODUCTIVE TISSUESQ3

PHYTOESTROGENQ3

Abstract

Hormonally active agents are widespread in the environment and exist in the human diet. There is insufficient knowledge regarding the influence of phytochemicals on the pathophysiology of the male reproductive system. Kiwi is a rich source of phytochemicals such as flavones (with estrogenic activity), serotonin and vitamin C. These components can influence the hormones and interfere with reproductive activities. Therefore, the objective of this project was to determine whether extract of kiwi could change the structure of male REPRODUCTIVE TISSUES. So, 40 male rats were divided into four groups. Three experimental groups were fed with 75, 100 and 150 mg/kg of kiwi extract and control groups with solvent for 50 days. Then, rats were sacrificed and their TESTIS, ductus deferens, seminal vesicle, prostate and epididymidis were removed, fixed, processed and stained with H & E and Acridine Orange. The specimens were studied under light and fluorescent microscopes. Histological observations revealed some changes in the structure of testes, but not in the other parts of male REPRODUCTIVE TISSUES. Some spermatocytes have become fusiform and the number of these cells has been increased, dose dependently. There were many spermatocyes at the metaphase stage, among 100 and 150 mg/kg treated groups; Some of the mitotic figures, sperm, most of the spermatogonia and spermatocytes stained red with Acridine Orange, which indicats denaturation of DNA strands. A few fragmented nuclei were also observed in the 150mg/kg treated group. In conclusion, it seems that extract of kiwi can change the spermatocyte cytoarchitecture and affects the spermatogonia and spermatozoa. It may exert dual effects on the proliferating cells, such as spermatogenesis linage. In low concentrations it could induce proliferation, and in high concentrations, it may lead to cell death and nucleus fragmentation. The extract may elongate the period of the metaphase.

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APA: Copy

DEHGHANI, FARZANEH, TALAEI KHOUZANI, T., PANJEH SHAHIN, M.R., & PANAHI, Z.. (2006). TOXIC EFFECTS OF HYDROALCOHOLIC EXTRACT OF KIWI (ACTINIDIA CHINENSIS) ON HISTOLOGICAL STRUCTURE OF THE MALE SPRAGUE-DAWLEY RAT REPRODUCTIVE TISSUES. IRANIAN JOURNAL OF SCIENCE AND TECHNOLOGY TRANSACTION A- SCIENCE, 30(A1), 19-25. SID. https://sid.ir/paper/117926/en

Vancouver: Copy

DEHGHANI FARZANEH, TALAEI KHOUZANI T., PANJEH SHAHIN M.R., PANAHI Z.. TOXIC EFFECTS OF HYDROALCOHOLIC EXTRACT OF KIWI (ACTINIDIA CHINENSIS) ON HISTOLOGICAL STRUCTURE OF THE MALE SPRAGUE-DAWLEY RAT REPRODUCTIVE TISSUES. IRANIAN JOURNAL OF SCIENCE AND TECHNOLOGY TRANSACTION A- SCIENCE[Internet]. 2006;30(A1):19-25. Available from: https://sid.ir/paper/117926/en

IEEE: Copy

FARZANEH DEHGHANI, T. TALAEI KHOUZANI, M.R. PANJEH SHAHIN, and Z. PANAHI, “TOXIC EFFECTS OF HYDROALCOHOLIC EXTRACT OF KIWI (ACTINIDIA CHINENSIS) ON HISTOLOGICAL STRUCTURE OF THE MALE SPRAGUE-DAWLEY RAT REPRODUCTIVE TISSUES,” IRANIAN JOURNAL OF SCIENCE AND TECHNOLOGY TRANSACTION A- SCIENCE, vol. 30, no. A1, pp. 19–25, 2006, [Online]. Available: https://sid.ir/paper/117926/en

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