The Effect of Eight Weeks Moderate-Intensity Endurance Training With Saffron Intake on Memory and Learning in Rats With Trimethytin Model of Alzheimer’ s Disease

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AKBARI FATEMEH; MOGHADASI MEHRZAD; Farsi Sirus; EDALATMANESH MOHAMMAD AMIN

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Journal: JOURNAL OF APPLIED EXERCISE PHYSIOLOGY (JOURNAL OF SPORTS SCIENCE) Year:2020 | Volume:15 | Issue:30 Page(s): 115-128

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Title

The Effect of Eight Weeks Moderate-Intensity Endurance Training With Saffron Intake on Memory and Learning in Rats With Trimethytin Model of Alzheimer’ s Disease

Author(s)

AKBARI FATEMEH | MOGHADASI MEHRZAD | Farsi Sirus | EDALATMANESH MOHAMMAD AMIN | Issue Writer Certificate

Keywords

Endurance TrainingQ2

Saffron SupplementQ1

Working MemoryQ1

Avoidance MemoryQ1

Alzheimer’s DiseaseQ1

Abstract

Background Purpose: Although studies that emphasize the importance of exercise exist, the interaction effects of exercise with saffron intake on cognitive functions in Alzheimer’ s patients are not well known. The aim of present study was to examine the effect of eight weeks Endurance Training with saffron intake on Working Memory and passive Avoidance Memory in rats treated with neurotoxin as a model of Alzheimer’ s disease. Methodology: Forty mature Sprague-dawley male rats were subjected to Alzheimer’ s disease through intraperitoneally injection of 8 mg/kg Trimethytin (TMT) and then were divided into 1) Alzheimer-infected control group, 2) Endurance Training, 3) Endurance Training with saffron intake, 4) saffron intake, and 5) sham to study the impact of the disease on the variables. Eight healthy rats were assigned to the control group. The rats in the second and the third groups ran on a rat treadmill with the speed of 15 to 20 meters per minute for 15 to 30 minutes in each session, 3 times a week for 8 weeks. The rats in the third and the fourth groups received daily IP injections of 25 mg/kg body weight of saffron liquid extract for 8 weeks. Working Memory and passive Avoidance Memory were measured through Y-maze test and shuttle box text, respectively. To analyze the results of the tests, one-way ANOVA, Tukey post hoc test, and two-way ANOVA were run using SPSS. Results: The data indicated that the Endurance Training alone and the intake of saffron liquid extract could significantly improve the Working Memory (F=11. 09 and P=0. 002 for Endurance Training and F=7. 51 and P=0. 01 for saffron liquid) and passive Avoidance Memory (F=22. 20 and P=0. 001 for Endurance Training and F=25. 83 and P=0. 01 for saffron liquid) in Alzheimer-infected rats. Also, the effect of the interaction of the Endurance Training and the saffron liquid extract in reducing the time spent in the dark chamber was significant (F=23. 07 and P=0. 001) while this interaction was not significant in increasing the time spent in the dark chamber and the percentage of the intermittent behavior of the rats in the TMT model of Alzheimer’ s disease. Conclusion: It seems that Endurance Training and saffron liquid extract intake, improve the Working Memory and passive avoidance in rats with Alzheimer’ s disease in TMT model.

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APA: Copy

AKBARI, FATEMEH, MOGHADASI, MEHRZAD, Farsi, Sirus, & EDALATMANESH, MOHAMMAD AMIN. (2020). The Effect of Eight Weeks Moderate-Intensity Endurance Training With Saffron Intake on Memory and Learning in Rats With Trimethytin Model of Alzheimer’ s Disease. JOURNAL OF APPLIED EXERCISE PHYSIOLOGY (JOURNAL OF SPORTS SCIENCE), 15(30 ), 115-128. SID. https://sid.ir/paper/129591/en

Vancouver: Copy

AKBARI FATEMEH, MOGHADASI MEHRZAD, Farsi Sirus, EDALATMANESH MOHAMMAD AMIN. The Effect of Eight Weeks Moderate-Intensity Endurance Training With Saffron Intake on Memory and Learning in Rats With Trimethytin Model of Alzheimer’ s Disease. JOURNAL OF APPLIED EXERCISE PHYSIOLOGY (JOURNAL OF SPORTS SCIENCE)[Internet]. 2020;15(30 ):115-128. Available from: https://sid.ir/paper/129591/en

IEEE: Copy

FATEMEH AKBARI, MEHRZAD MOGHADASI, Sirus Farsi, and MOHAMMAD AMIN EDALATMANESH, “The Effect of Eight Weeks Moderate-Intensity Endurance Training With Saffron Intake on Memory and Learning in Rats With Trimethytin Model of Alzheimer’ s Disease,” JOURNAL OF APPLIED EXERCISE PHYSIOLOGY (JOURNAL OF SPORTS SCIENCE), vol. 15, no. 30 , pp. 115–128, 2020, [Online]. Available: https://sid.ir/paper/129591/en

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