The Effect of High Intensity Interval Training Preconditioning on Klotho and TNF-α Female Mice with Multiple Sclerosis

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Farahmand Fatane; Nourshahi Maryan; SOLEIMANI MARYAM; RAJABI HAMID; Power Kevin

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Journal: JOURNAL OF APPLIED EXERCISE PHYSIOLOGY (JOURNAL OF SPORTS SCIENCE) Year:2020 | Volume:15 | Issue:30 Page(s): 15-29

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Title

The Effect of High Intensity Interval Training Preconditioning on Klotho and TNF-α Female Mice with Multiple Sclerosis

Author(s)

Keywords

Multiple sclerosisQ2

PLPQ1

High intensity interval trainingQ1

CerebellumQ1

Abstract

Background Purpose Exercise activity plays an important role in increasing biomarkers such as Klotho and PLP and improves clinical outcome in mice with MS. In the present study, we evaluated whether 6 weeks of high-intensity interval training (HIIT) increases Klotho or PLP levels and decreased TNF-α in Cerebellum tissue. Methodology: Animals were divided into two groups of training (EX) and control (Con). After 4 weeks, the exercise and control groups were divided into two groups and EAE was induced in half of the animals in the control and EX groups. In the EX-6 weeks group after 4 weeks of training, EAE induction and training protocol continued until the sixth week. In the EX-4 weeks group after 4 weeks of training, EAE was induced and the training was stopped. Results: Klotho and PLP levels increased in the EAE-EX1 group compared to the EAE and EAE-EX2 groups (P≤ 0. 0001). Also, demyelination levels decreased in the EAE-EX1 group compared to the EAE group (P≤ 0. 007). TNF-α concentration decreased in both EAE-exercise groups (P≤ 0. 0001). Conclusion: The results of this study showed that HIIT increased Klotho and PLP levels and improved clinical outcomes in the in mice with MS.

Cites

Effect of eight weeks of resistance training on the expression of klotho protein and insulin-like growth factor 1 genes in slow twitch and fast twitch skeletal muscles of aged Wistar rats

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APA: Copy

Farahmand, Fatane, Nourshahi, Maryan, SOLEIMANI, MARYAM, RAJABI, HAMID, & Power, Kevin. (2020). The Effect of High Intensity Interval Training Preconditioning on Klotho and TNF-α Female Mice with Multiple Sclerosis. JOURNAL OF APPLIED EXERCISE PHYSIOLOGY (JOURNAL OF SPORTS SCIENCE), 15(30 ), 15-29. SID. https://sid.ir/paper/129593/en

Vancouver: Copy

Farahmand Fatane, Nourshahi Maryan, SOLEIMANI MARYAM, RAJABI HAMID, Power Kevin. The Effect of High Intensity Interval Training Preconditioning on Klotho and TNF-α Female Mice with Multiple Sclerosis. JOURNAL OF APPLIED EXERCISE PHYSIOLOGY (JOURNAL OF SPORTS SCIENCE)[Internet]. 2020;15(30 ):15-29. Available from: https://sid.ir/paper/129593/en

IEEE: Copy

Fatane Farahmand, Maryan Nourshahi, MARYAM SOLEIMANI, HAMID RAJABI, and Kevin Power, “The Effect of High Intensity Interval Training Preconditioning on Klotho and TNF-α Female Mice with Multiple Sclerosis,” JOURNAL OF APPLIED EXERCISE PHYSIOLOGY (JOURNAL OF SPORTS SCIENCE), vol. 15, no. 30 , pp. 15–29, 2020, [Online]. Available: https://sid.ir/paper/129593/en

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